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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ma, Ning Wang, Zhenyu Chen, Hao Sun, Yanjun Hong, Haifa Sun, Qi Yin, Meng Liu, Jinfen |
| Copyright Year | 2011 |
| Abstract | To accelerate the fabrication of thick-walled autologous tissue-engineered vascular grafts (TEVGs), a novel biotube inserting technique was developed. After 2 weeks of subcutaneous embedding in rabbits, silicone rods (diameter, 3 mm; length, 35 mm) became encapsulated in connective tissues. Single-layered biotubes were obtained after removing the silicone rods. One silicone rod encapsulated in tissues was inserted into a single-layered biotube to form two layers of autologous tubular tissues. Three layers of autologous tubular tissues were also obtained by applying the same technique. Following a 2-week re-embedding procedure, two layers or three layers of autologous tubular tissues were integrated to form two-layered or three-layered TEVGs. Both wall thickness and burst pressure of three-layered TEVGs were significantly higher than those of two-layered and single-layered TEVGs (P < 0.05). The two-layered TEVGs could be applied as small-caliber vascular grafts, and three-layered TEVGs could be applied as medium- or large-caliber vascular grafts. |
| Starting Page | 1037 |
| Ending Page | 1043 |
| Page Count | 7 |
| File Format | |
| ISSN | 09574530 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume Number | 22 |
| Issue Number | 4 |
| e-ISSN | 15734838 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2011-02-18 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | Metallic Materials Characterization and Evaluation of Materials Biomaterials Surfaces and Interfaces, Thin Films Ceramics, Glass, Composites, Natural Methods Polymer Sciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biophysics Bioengineering Biomedical Engineering |
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