NDLI: Synthesis of novel tricalcium phosphate-bioactive glass composite and functionalization with rhBMP-2

Content Provider	Springer Nature Link
Author	Schickle, Karolina Zurlinden, Kristin Bergmann, Christian Lindner, Markus Kirsten, Armin Laub, Markus Telle, Rainer Jennissen, Herbert Fischer, Horst
Copyright Year	2011
Abstract	A functionalization is required for calcium phosphate-based bone substitute materials to achieve an entire bone remodeling. In this study it was hypothesized that a tailored composite of tricalcium phosphate and a bioactive glass can be loaded sufficiently with rhBMP-2 for functionalization. A composite of 40 wt% tricalcium phosphate and 60 wt% bioactive glass resulted in two crystalline phases, wollastonite and rhenanite after sintering. SEM analysis of the composite’s surface revealed a spongious bone-like morphology after treatment with different acids. RhBMP-2 was immobilized non-covalently by treating with chrome sulfuric acid (CSA) and 3-aminopropyltriethoxysilane (APS) and covalently by treating with CSA/APS, and additionally with 1,1′-carbonyldiimidazole. It was proved that samples containing non-covalently immobilized rhBMP-2 on the surface exhibit significant biological activity in contrast to the samples with covalently bound protein on the surface. We conclude that a tailored composite of tricalcium phosphate and bioactive glass can be loaded sufficiently with BMP-2.
Starting Page	763
Ending Page	771
Page Count	9
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	22
Issue Number	4
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2011-02-10
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Metallic Materials Characterization and Evaluation of Materials Biomaterials Surfaces and Interfaces, Thin Films Ceramics, Glass, Composites, Natural Methods Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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