NDLI: Surface modification of polydimethylsiloxane (PDMS) induced proliferation and neural-like cells differentiation of umbilical cord blood-derived mesenchymal stem cells

Content Provider	Springer Nature Link
Author	Kim, Sun Jung Lee, Jae Kyoo Kim, Jin Won Jung, Ji Won Seo, Kwangwon Park, Sang Bum Roh, Kyung Hwan Lee, Sae Rom Hong, Yun Hwa Kim, Sang Jeong Lee, Yong Soon Kim, Sung June Kang, Kyung Sun
Copyright Year	2008
Abstract	Stem cell-based therapy has recently emerged for use in novel therapeutics for incurable diseases. For successful recovery from neurologic diseases, the most pivotal factor is differentiation and directed neuronal cell growth. In this study, we fabricated three different widths of a micro-pattern on polydimethylsiloxane (PDMS; 1, 2, and 4 μm). Surface modification of the PDMS was investigated for its capacity to manage proliferation and differentiation of neural-like cells from umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs). Among the micro-patterned PDMS fabrications, the 1 μm-patterned PDMS significantly increased cell proliferation and most of the cells differentiated into neuronal cells. In addition, the 1 μm-patterned PDMS induced an increase in cytosolic calcium, while the differentiated cells on the flat and 4 μm-patterned PDMS had no response. PDMS with a 1 μm pattern was also aligned to direct orientation within 10° angles. Taken together, micro-patterned PDMS supported UCB-MSC proliferation and induced neural like-cell differentiation. Our data suggest that micro-patterned PDMS might be a guiding method for stem cell therapy that would improve its therapeutic action in neurological diseases.
Starting Page	2953
Ending Page	2962
Page Count	10
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	19
Issue Number	8
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2008-03-24
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Surfaces and Interfaces, Thin Films Characterization and Evaluation of Materials Metallic Materials Ceramics, Glass, Composites, Natural Methods Polymer Sciences Biomaterials
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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