NDLI: An extended spectrum bactericidal titanium dioxide (TiO$_{2}$) coating for metallic implants: in vitro effectiveness against MRSA and mechanical properties

Content Provider	Springer Nature Link
Author	Haenle, Maximilian Fritsche, Andreas Zietz, Carmen Bader, Rainer Heidenau, Frank Mittelmeier, Wolfram Gollwitzer, Hans
Copyright Year	2010
Abstract	Implant infections remain feared and severe complications after total joint arthroplasty. The incidence of multi-resistant pathogens, causing such infections, is rising continuously, and orthopaedic surgeons are confronted with an ever-changing resistance pattern. Anti-infectious surface coatings aim for a high local effective concentration and a low systemic toxicity at the same time. Antibacterial efficacy and biomechanical stability of a novel broad-spectrum anti-infectious coating is assessed in the present study. Antibacterial efficacy of a sol–gel derived titanium dioxide (TiO$_{2}$) coating for metal implants with and without integrated copper ions as antibiotic agent was assessed against methicillin resistant Staphylococcus aureus (MRSA 27065). Both bacterial surface adhesion and growth of planktonic bacteria were assessed with bare and various TiO$_{2}$-coated Ti6Al4V metal discs. Furthermore, bonding strength of the TiO$_{2}$ surface coating, using standard testing procedures, as well as surface roughness were determined. We found a significant reduction of the bacterial growth rate for the coatings with integrated copper ions, with highest reduction rates observed for a fourfold copper TiO$_{2}$-coating. Pure TiO$_{2}$ without integrated copper ions did not reduce bacterial growth compared to uncoated Ti6Al4V. The coating was not detached from the substrate by standard adhesive failure testing, which indicated an excellent durability of the implant coating. The TiO$_{2}$ coating with integrated copper ions could offer a new strategy for preventing implant-associated infections, with antibacterial properties not only against the most common bacteria causing implant infections but also against multiresistant strains such as MRSA.
Starting Page	381
Ending Page	387
Page Count	7
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	22
Issue Number	2
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2010-12-29
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Metallic Materials Polymer Sciences Surfaces and Interfaces, Thin Films Ceramics, Glass, Composites, Natural Methods Biomaterials Characterization and Evaluation of Materials
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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