NDLI: Evaluation of two polymeric blends (EVA/PLA and EVA/PEG) as coating film materials for paclitaxel-eluting stent application

Content Provider	Springer Nature Link
Author	Liu, Xi Lei, Lei Hou, Jing Wen Tang, Mu Fei Guo, Sheng Rong Wang, Zhong Min Chen, Ke Min
Copyright Year	2010
Abstract	The ethylene vinyl acetate copolymer (EVA)/Poly (lactic acid) (PLA) blend and EVA/Poly (ethylene glycol) (PEG) blend were applied as the drug carrier materials for a bi-layer drug-loaded stent coating film, which consisted of a paclitaxel (PTX)-loaded layer and a drug-free EVA layer. The changes of weight and appearance of the drug-free polymeric blend films with increasing time were examined by X-ray diffraction analysis (XRD), gel permeation chromatography (GPC) tests and scanning electronic microscopy (SEM), and the results showed the degradation of PLA and the leaching of PEG from the films. The effects of PLA, PEG and drug contents on in vitro drug release were investigated, and the results demonstrated that the addition of PLA promoted the drug release while the addition of PEG almost did not. Franz cells diffusion test results indicated that the bi-layer structure successfully endowed the stent coating with the release of drug in a unidirectional fashion. The release profiles of films incorporated PTX and the mechanical performance of the film could be customized by readily adjusting the contents of the blend components. Therefore, the polymeric blends could be useful drug carrier materials for drug-loaded stent coating capable of releasing drug in a highly tunable manner.
Starting Page	327
Ending Page	337
Page Count	11
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	22
Issue Number	2
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2011-01-08
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Metallic Materials Polymer Sciences Surfaces and Interfaces, Thin Films Ceramics, Glass, Composites, Natural Methods Biomaterials Characterization and Evaluation of Materials
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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