NDLI: Implants of polyanionic collagen matrix in bone defects of ovariectomized rats

Content Provider	Springer Nature Link
Author	Cunha, Marcelo Rodrigues Santos, Arnaldo Rodrigues Goissis, Gilberto Genari, Selma C.
Copyright Year	2007
Abstract	In recent years, there has been a great interest in the development of biomaterials that could be used in the repair of bone defects. Collagen matrix (CM) has the advantage that it can be modified chemically to improve its mechanical properties. The aim of the present study was to evaluate the effect of three-dimensional membranes of native or anionic (submitted to alkaline treatment for 48 or 96 h) collagen matrix on the consolidation of osteoporosis bone fractures resulting from the gonadal hormone alterations caused by ovariectomy in rats subjected to hormone replacement therapy. The animals received the implants 4 months after ovariectomy and were sacrificed 8 weeks after implantation of the membranes into 4-mm wide bone defects created in the distal third of the femur with a surgical bur. Macroscopic analysis revealed the absence of pathological alterations in the implanted areas, suggesting that the material was biocompatible. Microscopic analysis showed a lower amount of bone ingrowth in the areas receiving the native membrane compared to the bone defects filled with the anionic membranes. In ovariectomized animals receiving anionic membranes, a delay in bone regeneration was observed mainly in animals not subjected to hormone replacement therapy. We conclude that anionic membranes treated with alkaline solution for 48 and 96 h presented better results in terms of bone ingrowth.
Starting Page	1341
Ending Page	1348
Page Count	8
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	19
Issue Number	3
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2007-10-04
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Surfaces and Interfaces, Thin Films Ceramics, Glass, Composites, Natural Methods Metallic Materials Polymer Sciences Characterization and Evaluation of Materials Biomaterials
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Regeneration of critical bone defects with anionic collagen matrix as scaffolds

Effect of calcium phosphate glass on bone formation in calvarial defects of Sprague-Dawley rats

Collagen-hydroxyapatite composite enhances regeneration of calvaria bone defects in young rats but postpones the regeneration of calvaria bone in aged rats

Orthotropic index for bone

Evaluation of bone matrix and demineralized bone matrix incorporated PLGA matrices for bone repair

Mineralised collagen—an artificial, extracellular bone matrix—improves osteogenic differentiation of bone marrow stromal cells

Repair of rabbit femoral condyle bone defects with injectable nanohydroxyapatite/chitosan composites

Bone mineral crystallisation kinetics

Biocompatible glass–ceramic materials for bone substitution

Implants of polyanionic collagen matrix in bone defects of ovariectomized rats

Similar Documents

Regeneration of critical bone defects with anionic collagen matrix as scaffolds

Effect of calcium phosphate glass on bone formation in calvarial defects of Sprague-Dawley rats

Collagen-hydroxyapatite composite enhances regeneration of calvaria bone defects in young rats but postpones the regeneration of calvaria bone in aged rats

Orthotropic index for bone

Evaluation of bone matrix and demineralized bone matrix incorporated PLGA matrices for bone repair

Mineralised collagen—an artificial, extracellular bone matrix—improves osteogenic differentiation of bone marrow stromal cells

Repair of rabbit femoral condyle bone defects with injectable nanohydroxyapatite/chitosan composites

Bone mineral crystallisation kinetics

Biocompatible glass–ceramic materials for bone substitution

Implants of polyanionic collagen matrix in bone defects of ovariectomized rats