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| Content Provider | Springer Nature Link |
|---|---|
| Author | Jones, Julian R. Ehrenfried, Lisa M. Saravanapavan, Priya Hench, Larry L. |
| Copyright Year | 2006 |
| Abstract | Bioactive glass scaffolds have been produced, which meet many of the criteria for an ideal scaffold for bone tissue engineering applications, by foaming sol-gel derived bioactive glasses. The scaffolds have a hierarchical pore structure that is very similar to that of cancellous bone. The degradation products of bioactive glasses have been found to stimulate the genes in osteoblasts. This effect has been found to be dose dependent. The addition of silver ions to bioactive glasses has also been investigated to produce glasses with bactericidal properties. This paper discusses how changes in the hierarchical pore structure affect the dissolution of the glass and therefore its bioactivity and rate of ion delivery and demonstrates that silver containing bioactive glass foam scaffolds can be synthesised. It was found that the rate of release of Si and Ca ions was more rapid for pore structures with a larger modal pore diameter, although the effect of tailoring the textural porosity on the rate of ion release was more pronounced. Bioactive glass scaffolds, containing 2 mol% silver, released silver ions at a rate that was similar to that which has previously been found to be bactericidal but not high enough to be cytotoxic to bone cells. |
| Starting Page | 989 |
| Ending Page | 996 |
| Page Count | 8 |
| File Format | |
| ISSN | 09574530 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume Number | 17 |
| Issue Number | 11 |
| e-ISSN | 15734838 |
| Language | English |
| Publisher | Kluwer Academic Publishers |
| Publisher Date | 2006-11-22 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | Polymer Sciences Biomaterials Metallic Materials Characterization and Evaluation Materials Ceramics, Glass, Composites, Natural Methods Surfaces and Interfaces, Thin Films |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biophysics Bioengineering Biomedical Engineering |
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