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| Content Provider | Springer Nature Link |
|---|---|
| Author | Cascone, Maria Grazia Lazzeri, Luigi Carmignani, Claudia Zhu, Zhouhai |
| Copyright Year | 2002 |
| Abstract | Biodegradable hydrophilic gelatin nanoparticles, containing different initial amounts of methotrexate (MTX), were prepared using a simple solvent evaporation technique based on a single water-in-oil emulsion and stabilized by the use of glutaraldehyde as cross-linking agent. The effects of several parameters on particle size, drug encapsulation efficiency and drug release were investigated. Size and shape of the nanoparticles were examined by scanning electron microscopy. The release of MTX was monitored in vitro and the mechanism of release was studied. Particles with a mean diameter of 100–200 nm were produced, which were able to release MTX following a diffusion-controlled mechanism of release. It was observed that the initial amount of MTX used for sample loading did not have any effect on the pattern of release, while it affected the amount of drug entrapped into the nanoparticles and also both the release rate and the total amount of drug released. |
| Starting Page | 523 |
| Ending Page | 526 |
| Page Count | 4 |
| File Format | |
| ISSN | 09574530 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume Number | 13 |
| Issue Number | 5 |
| e-ISSN | 15734838 |
| Language | English |
| Publisher | Kluwer Academic Publishers |
| Publisher Date | 2002-01-01 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | Biotechnology Polymer Sciences Characterization and Evaluation Materials |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biophysics Bioengineering Biomedical Engineering |
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