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| Content Provider | Springer Nature Link |
|---|---|
| Author | Kirkland, Nicholas T. Waterman, Jay Birbilis, Nick Dias, George Woodfield, Tim B. F. Hartshorn, Richard M. Staiger, Mark P. |
| Copyright Year | 2011 |
| Abstract | Magnesium (Mg) alloys are being actively investigated as potential load-bearing orthopaedic implant materials due to their biodegradability in vivo. With Mg biomaterials at an early stage in their development, the screening of alloy compositions for their biodegradation rate, and hence biocompatibility, is reliant on cost-effective in vitro methods. The use of a buffer to control pH during in vitro biodegradation is recognised as critically important as this seeks to mimic pH control as it occurs naturally in vivo. The two different types of in vitro buffer system available are based on either (i) zwitterionic organic compounds or (ii) carbonate buffers within a partial-CO$_{2}$ atmosphere. This study investigated the influence of the buffering system itself on the in vitro corrosion of Mg. It was found that the less realistic zwitterion-based buffer did not form the same corrosion layers as the carbonate buffer, and was potentially affecting the behaviour of the hydrated oxide layer that forms on Mg in all aqueous environments. Consequently it was recommended that Mg in vitro experiments use the more biorealistic carbonate buffering system when possible. |
| Starting Page | 283 |
| Ending Page | 291 |
| Page Count | 9 |
| File Format | |
| ISSN | 09574530 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume Number | 23 |
| Issue Number | 2 |
| e-ISSN | 15734838 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2011-12-22 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | Metallic Materials Biomaterials Ceramics, Glass, Composites, Natural Methods Surfaces and Interfaces, Thin Films Characterization and Evaluation of Materials Polymer Sciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biophysics Bioengineering Biomedical Engineering |
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