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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ren, Li Mei Arahira, Takaaki Todo, Mitsugu Yoshikawa, Hideki Myoui, Akira |
| Copyright Year | 2011 |
| Abstract | Hydroxyapatite ceramics have been widely investigated for bone regeneration due to their high biocompatibility. However, few studies focus on their mechanical characteristics after implantation. In this study, the finite element (FE) method was used to evaluate the mechanical properties of a fully interconnected porous hydroxyapatite (IPHA) over time of implantation. Based on the micro-CT images obtained from the experiments dealing with IPHA implanted into rabbit femoral condyles, three-dimensional FE models of IPHA (1, 5, 12, 24, and 48 weeks after implantation) were developed. FE analysis indicated that the elastic modulus gradually increased from 1 week and reached the peak value at 24 weeks, and then it kept at high level until 48 weeks postoperatively. In addition, as a local biomechanical response, strain energy density became to distribute evenly over time after the implantation. Results confirmed that the mechanical properties of IPHA are strongly correlated to bone ingrowth. The efficiency of the proposed numerical approach was validated in combination with experimental studies, and the feasibility of applying this approach to study such implanted porous bioceramics was proved. |
| Starting Page | 463 |
| Ending Page | 472 |
| Page Count | 10 |
| File Format | |
| ISSN | 09574530 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume Number | 23 |
| Issue Number | 2 |
| e-ISSN | 15734838 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2011-11-23 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | Metallic Materials Biomaterials Ceramics, Glass, Composites, Natural Methods Surfaces and Interfaces, Thin Films Characterization and Evaluation of Materials Polymer Sciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biophysics Bioengineering Biomedical Engineering |
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