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| Content Provider | Springer Nature Link |
|---|---|
| Author | Zheng, Zengjuan Zhang, Weifen Sun, Weiqing Li, Xiaojian Duan, Jinghua Cui, Juanjuan Feng, Zhanqin Mansour, Heidi M. |
| Copyright Year | 2013 |
| Abstract | The aim of this paper was to investigate the effect of carboxymethyl chitosan anti-adhesion solution on prevention of postsurgical adhesion. Forty adult male Wistar rats were randomly divided into three groups: 0.9 % normal saline solution (group A), hyaluronic acid gels (group B) and carboxymethyl chitosan anti-adhesion solution (group C). The animals were treated with normal saline, hyaluronic acid gels or carboxymethyl chitosan anti-adhesion solution at the time of surgery. After 2 or 3 weeks, the degree of adhesions and histological effects were determined. The adhesions in groups B and C were significantly decreased, and the levels of TGF-β$_{1}$ and hydroxyproline in group C were significantly lower than that in group A (P < 0.05). The histopathology in group C showed fewer inflammatory cells and fibroblasts. Carboxymethyl chitosan anti-adhesion solution can effectively prevent postoperative adhesion which is a promising drug delivery system in the context of postsurgical anti-adhesion. |
| Starting Page | 2549 |
| Ending Page | 2559 |
| Page Count | 11 |
| File Format | |
| ISSN | 09574530 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume Number | 24 |
| Issue Number | 11 |
| e-ISSN | 15734838 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2013-07-03 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | Biomaterials Polymer Sciences Ceramics, Glass, Composites, Natural Methods Metallic Materials Characterization and Evaluation of Materials Surfaces and Interfaces, Thin Films |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biophysics Bioengineering Biomedical Engineering |
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