NDLI: Anti-washout carboxymethyl chitosan modified tricalcium silicate bone cement: preparation, mechanical properties and in vitro bioactivity

Content Provider	Springer Nature Link
Author	Lin, Qing Lan, Xianghui Li, Yanbao Yu, Yinhui Ni, Yaru Lu, Chunhua Xu, Zhongzi
Copyright Year	2010
Abstract	Anti-washout CaF$_{2}$ stabilized C$_{3}$S (F-C$_{3}$S) bone cement was prepared by adding water-soluble carboxymethyl chitosan (CMCS) to the hydration liquid. The setting time, compressive strength and in vitro bioactivity of the CMCS modified F-C$_{3}$S (CMCS–C$_{3}$S) pastes were evaluated. The results indicate that CMCS–C$_{3}$S pastes could be stable in the shaking simulated body fluid (SBF) after immediately mixed. The addition of CMCS significantly enhances the cohesion of particles, at the same time restrains the penetration of liquid, and thus endows the anti-washout ability. The setting times of the pastes increase with the increase of CMCS concentrations in the hydration liquid. Besides, the compressive strengths of CMCS–C$_{3}$S pastes after setting for 1–28 days are lower than that of the pure F-C$_{3}$S paste, but the sufficient strengths would be suitable for the clinical applications. The crystalline apatite deposited on the paste surface is retarded from 1 to 2 days for the addition of CMCS, but the quantities of deposited apatite are same after soaking in SBF for 3 days. As the result that pure C$_{3}$S paste has shorter setting times than pure F-C$_{3}$S paste, CMCS modified pure C$_{3}$S pastes would have better anti-washout ability. Our study provides a convenient way to use C$_{3}$S bone cement with excellent anti-washout ability when the pastes are exposed to biological fluids. The novel anti-washout CMCS–C$_{3}$S bone cement with suitable setting times, sufficient strengths and in vitro bioactivity would have good prospects for medical application.
Starting Page	3065
Ending Page	3076
Page Count	12
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	21
Issue Number	12
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2010-10-02
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Surfaces and Interfaces, Thin Films Characterization and Evaluation of Materials Metallic Materials Ceramics, Glass, Composites, Natural Methods Polymer Sciences Biomaterials
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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