NDLI: Influence of polymeric additives on the cohesion and mechanical properties of calcium phosphate cements

Content Provider	Springer Nature Link
Author	An, Jie Wolke, Joop G. C. Jansen, John A. Leeuwenburgh, Sander C. G.
Copyright Year	2016
Abstract	To expand the clinical applicability of calcium phosphate cements (CPCs) to load-bearing anatomical sites, the mechanical and setting properties of CPCs need to be improved. Specifically, organic additives need to be developed that can overcome the disintegration and brittleness of CPCs. Hence, we compared two conventional polymeric additives (i.e. carboxylmethylcellulose (CMC) and hyaluronan (HA)) with a novel organic additive that was designed to bind to calcium phosphate, i.e. hyaluronan–bisphosphonate (HABP). The unmodified cement used in this study consisted of a powder phase of α-tricalcium phosphate (α-TCP) and liquid phase of 4 % NaH$_{2}$PO$_{4}$·2H$_{2}$O, while the modified cements were fabricated by adding 0.75 or 1.5 wt% of the polymeric additive to the cement. The cohesion of α-TCP was improved considerably by the addition of CMC and HABP. None of the additives improved the compression and bending strength of the cements, but the addition of 0.75 % HABP resulted into a significantly increased cement toughness as compared to the other experimental groups. The stimulatory effects of HABP on the cohesion and toughness of the cements is hypothesized to derive from the strong affinity between the polymer-grafted bisphosphonate ligands and the calcium ions in the cement matrix.
Starting Page	1
Ending Page	9
Page Count	9
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	27
Issue Number	3
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2016-01-19
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Biomaterials Biomedical Engineering Regenerative Medicine/Tissue Engineering Polymer Sciences Ceramics, Glass, Composites, Natural Methods Surfaces and Interfaces, Thin Films
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Porosity prediction of calcium phosphate cements based on chemical composition

Synthesis of Ag doped calcium phosphate particles and their antibacterial effect as additives in dental glass ionomer cements

Physicochemical properties and osteogenic activity of radiopaque calcium silicate–gelatin cements

Reaction kinetics of dual setting α-tricalcium phosphate cements

Biocompatibility of calcium phosphate bone cement with optimised mechanical properties: an in vivo study

Cytocompatibility of the selected calcium phosphate based bone cements: comparative study in human cell culture

Heat transfer properties and thermal cure of glass-ionomer dental cements

Compressive fatigue properties of an acidic calcium phosphate cement—effect of phase composition

Influences of the steam sterilization on the properties of calcium phosphate porous bioceramics

Influence of polymeric additives on the cohesion and mechanical properties of calcium phosphate cements

Similar Documents

Porosity prediction of calcium phosphate cements based on chemical composition

Synthesis of Ag doped calcium phosphate particles and their antibacterial effect as additives in dental glass ionomer cements

Physicochemical properties and osteogenic activity of radiopaque calcium silicate–gelatin cements

Reaction kinetics of dual setting α-tricalcium phosphate cements

Biocompatibility of calcium phosphate bone cement with optimised mechanical properties: an in vivo study

Cytocompatibility of the selected calcium phosphate based bone cements: comparative study in human cell culture

Heat transfer properties and thermal cure of glass-ionomer dental cements

Compressive fatigue properties of an acidic calcium phosphate cement—effect of phase composition

Influences of the steam sterilization on the properties of calcium phosphate porous bioceramics

Influence of polymeric additives on the cohesion and mechanical properties of calcium phosphate cements