NDLI: Solid lipid nanoparticles of ondansetron HCl for intranasal delivery: development, optimization and evaluation

Content Provider	Springer Nature Link
Author	Joshi, Ashwini S. Patel, Hitesh S. Belgamwar, Veena S. Agrawal, Anshuman Tekade, Avinash R.
Copyright Year	2012
Abstract	The present investigation deals with the development and statistical optimization of solid lipid nanoparticles (SLNs) of ondansetron HCl (OND) for intranasal (i.n.) delivery. SLNs were prepared using the solvent diffusion technique and a 2$^{3}$ factorial design. The concentrations of lipid, surfactant and cosurfactant were independent variables in this design, whereas, particle size and entrapment efficiency (EE) were dependent variables. The particle size of the SLNs was found to be 320–498 nm, and the EE was between 32.89 and 56.56 %. The influence of the lipid, surfactant and cosurfactant on the particle size and EE was studied. A histological study revealed no adverse response of SLNs on sheep nasal mucosa. Transmission electron microscopic analysis showed spherical shape particles. Differential scanning calorimetry and X-ray diffraction studies indicated that the drug was completely encapsulated in a lipid matrix. In vitro drug release studies carried out in phosphate buffer (pH 6.6) indicated that the drug transport was of Fickian type. Gamma scintigraphic imaging in rabbits after i.n. administration showed rapid localization of the drug in the brain. Hence, OND SLNs is a promising nasal delivery system for rapid and direct nose-to-brain delivery.
Starting Page	2163
Ending Page	2175
Page Count	13
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	23
Issue Number	9
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2012-07-17
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Polymer Sciences Ceramics, Glass, Composites, Natural Methods Metallic Materials Surfaces and Interfaces, Thin Films Characterization and Evaluation of Materials Biomaterials
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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