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| Content Provider | Springer Nature Link |
|---|---|
| Author | Guo, Yan Yuan, Tun Xiao, Zhanwen Tang, Pingping Xiao, Yumei Fan, Yujiang Zhang, Xingdong |
| Copyright Year | 2012 |
| Abstract | The network structure of a three-dimensional hydrogel scaffold dominates its performance such as mechanical strength, mass transport capacity, degradation rate and subsequent cellular behavior. The hydrogels scaffolds with interpenetrating polymeric network (IPN) structure have an advantage over the individual component gels and could simulate partly the structure of native extracellular matrix of cartilage tissue. In this study, to develop perfect cartilage tissue engineering scaffolds, IPN hydrogels of collagen/chondroitin sulfate/hyaluronan were prepared via two simultaneous processes of collagen self-assembly and cross linking polymerization of chondroitin sulfate-methacrylate (CSMA) and hyaluronic acid-methacrylate. The degradation rate, swelling performance and compressive modulus of IPN hydrogels could be adjusted by varying the degree of methacrylation of CSMA. The results of proliferation and fluorescence staining of rabbit articular chondrocytes in vitro culture demonstrated that the IPN hydrogels possessed good cytocompatibility. Furthermore, the IPN hydrogels could upregulate cartilage-specific gene expression and promote the chondrocytes secreting glycosaminoglycan and collagen II. These results suggested that IPN hydrogels might serve as promising hydrogel scaffolds for cartilage tissue engineering. |
| Starting Page | 2267 |
| Ending Page | 2279 |
| Page Count | 13 |
| File Format | |
| ISSN | 09574530 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume Number | 23 |
| Issue Number | 9 |
| e-ISSN | 15734838 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2012-05-26 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | Polymer Sciences Ceramics, Glass, Composites, Natural Methods Metallic Materials Surfaces and Interfaces, Thin Films Characterization and Evaluation of Materials Biomaterials |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biophysics Bioengineering Biomedical Engineering |
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