NDLI: Negatively charged gold nanoparticles as an intrinsic peroxidase mimic and their applications in the oxidation of dopamine

Content Provider	Springer Nature Link
Author	Liu, Yanping Wang, Cunwen Cai, Ning Long, Sihui Yu, Faquan
Copyright Year	2014
Abstract	Artificial inorganic peroxidase is of great interest due to its intrinsic advantages over natural counterpart. Negatively charged gold nanoparticles (AuNPs) were discovered to function like a peroxidase in the present study. Two AuNPs in different size were prepared and characterized by TEM, and assayed for peroxidase activity. Its catalytic activity was found to follow Michaelis–Menten kinetics. The negative surface charge notably improves the affinity toward a substrate TMB, proved by the determined kinetic parameters. The particles expressed optimal catalytic activity under mildly acidic environment and resistance to elevated temperature and increased concentration of sodium azide. The origin of the activity was investigated tentatively. Hydrogen peroxide-treated AuNPs exhibited an enhanced activity. EDTA temporarily blocked the activity partially, while thiol groups permanently blocked the activity completely. Tests imply that it is the surface Au$^{+}$ that provides the activity. The successful oxidation of dopamine, as an instance, under the action of AuNPs as a peroxidase was conducted. These studies would lead to a wide range of potential applications.
Starting Page	7143
Ending Page	7150
Page Count	8
File Format	PDF
ISSN	00222461
Journal	Journal of Materials Science
Volume Number	49
Issue Number	20
e-ISSN	15734803
Language	English
Publisher	Springer US
Publisher Date	2014-07-10
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Materials Science Characterization and Evaluation of Materials Polymer Sciences Continuum Mechanics and Mechanics of Materials Crystallography Mechanics
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Mechanics of Materials Mechanical Engineering Polymers and Plastics

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