NDLI: Enhencemnet of solubility and photostability of rutin by complexation with β-cyclodextrin and (2-hydroxypropyl)-β-cyclodextrin

Content Provider	Springer Nature Link
Author	Savic, Ivan M. Savic Gajic, Ivana M. Nikolic, Vesna D. Nikolic, Ljubisa B. Radovavic, Blaga C. Milenkovic Andjelkovic, Ana
Copyright Year	2016
Abstract	Rutin is a flavonoid and has found a wide application in the treatment of various chronic diseases such as cancer, diabetes, hypertension and hypercholesterolemia. The pharmaceutical application of rutin is limited due to its poor water solubility. One of the ways to enhance the solubility and stability is the formation of the inclusion complexes. The purpose of this study was to improve the solubility, antioxidative activity and photostability of rutin by preparation of the inclusion complexes with β-cyclodextrin (β-CD) and (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD). The inclusion complexes were structurally characterized using FT-IR, XRD, $^{1}$H NMR methods. The obtained results indicated that the complexation between rutin and cyclodextrins were successfully achieved in the mixture of ethanol and water 2:3 (v/v) at room temperature for 24 h. The study of phase-solubility was showed that the solubility of rutin was linearly increased in the solution of increasing amount of cyclodextrins, i.e. that the molar ratio was 1:1 in the complexes. The calculated values of stability constants were found to be 508.4 and 488.9 M$^{−1}$ for rutin:β-CD and rutin:HP-β-CD complexes, respectively. After preparation of inclusion complexes, the antioxidant activity of rutin was improved due to the increase of its scavenge capacity. The photostability study indicates that the complexed rutin was a more stable and protected from the effect of irradiation in compared with free rutin. The improvement in the physicochemical properties provide the opportunities to the inclusion complexes of rutin to use for design of the new pharmaceutical products with modified characteristics of active substance.
Starting Page	33
Ending Page	43
Page Count	11
File Format	PDF
ISSN	13883127
Journal	Journal of Inclusion Phenomena and Macrocyclic Chemistry
Volume Number	86
Issue Number	1-2
e-ISSN	15731111
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-07-11
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cyclodextrins Rutin Phase-SOLUBILITY Photostability Antioxidant activity Organic Chemistry Food Science Crystallography and Scattering Methods
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics Food Science

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