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| Content Provider | Springer Nature Link |
|---|---|
| Author | Tsao, Jung Ying Wu, Chien Pang Tsai, Hsieh Ho Peng, Kuang Chia Lin, Pi Yun Su, Shan Yu Chen, Lieh Der Tsai, Fuu Jen Tsai, Yuhsin |
| Copyright Year | 2011 |
| Abstract | The objective of this paper is to study the effect of hydroxypropyl-β-cyclodextrin (HP-β-CD) complexation on the aqueous solubility, structure, thermal stability, antioxidant activity, and tyrosinase inhibition of paeonol (PAE). The inclusion complex (PAE-HP-β-CD complex) of HP-β-CD and PAE was prepared by a freeze-drying method. Phase solubility tests showed that the stability constant of the inclusion complex was about 33.8 M$^{−1}$ at 25 °C. The experimental results of proton nuclear magnetic resonance (H-NMR) spectroscopy, differential scanning calorimetry (DSC) and X-ray diffraction (XRD) suggested that PAE was included by HP-β-CD to form the PAE-HP-β-CD complex. Furthermore, the thermogravimetric analysis (TGA) results showed that the thermal stability of PAE was improved when it was complexed with HP-β-CD. Comparing the antioxidant activity of PAE with that of the PAE-HP-β-CD complex at the same concentration revealed that the complex of PAE with HP-β-CD was better able to eliminate radical. Furthermore, the experimental results revealed that the formation of a complex with HP-β-CD increased the water solubility of PAE, improving its apparent inhibitive activity of tyrosinase. |
| Starting Page | 405 |
| Ending Page | 411 |
| Page Count | 7 |
| File Format | |
| ISSN | 09230750 |
| Journal | Journal of Inclusion Phenomena and Macrocyclic Chemistry |
| Volume Number | 72 |
| Issue Number | 3-4 |
| e-ISSN | 15731111 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2011-07-20 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Paeonol Hydroxypropyl-β-cyclodextrin Inclusion complex Chinese traditional medicine Crystallography Organic Chemistry Food Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Condensed Matter Physics Food Science |
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