NDLI: The Applied Validated Ultraviolet-Visible Spectrophotometric Method and the Kinetic Model of the Release of Gedunin from a Chitosan-Coated Liposome

Content Provider	Springer Nature Link
Author	Sahu, A. Kumar Jain, V.
Copyright Year	2016
Abstract	The aim of this study is to develop a simple and cost-effective ultraviolet-visible spectrophotometric method, validated according to the International Harmonization Guidelines for the determination of gedunin from a chitosan-coated liposome. The liposome was prepared using the conventional thin film hydration method. The absorption maximum in methanol was found to be 220 nm. The linearity was followed in the concentration from 5–25 μg/mL with a high correlation coefficient of 0.999. The detection and quantification limits were found to be 0.2062 and 0.6250 μg/mL. This method was shown to be precise at the intraday (relative standard deviation <0.3%) and interday (relative standard deviation <1.0539%) level and accurate with recoveries between 98.6540–99.9123% (relative standard deviation <0.4%). The results of the method robustness study indicate that the method was robust. The method was used to determine encapsulation efficiency and the release profile from a coated liposome. Kinetic models (zero order, first order, Higuchi, Hixson–Crowell, and Korsmeyer–Peppas) were used to fit the obtained release profile and to predict the in vivo performance of a Gedunin containing coated liposome.
Starting Page	878
Ending Page	887
Page Count	10
File Format	PDF
ISSN	00219037
Journal	Journal of Applied Spectroscopy
Volume Number	83
Issue Number	5
e-ISSN	15738647
Language	English
Publisher	Springer US
Publisher Date	2016-11-08
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Gedunin liposome validation ultraviolet-visible spectroscopy kinetic model release profile Atomic/Molecular Structure and Spectra Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Condensed Matter Physics

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