NDLI: Spectrophotometric Method for Differentiation of Human Skin Melanoma. II. Diagnostic Characteristics

Content Provider	Springer Nature Link
Author	Petruk, V. G. Ivav, A. P. Kvaternyuk, S. M. Barunb, V. V.
Copyright Year	2016
Abstract	Experimental data on the spectral dependences of the optical diffuse reflection coefficient for skin from different people with melanoma or nevus are presented in the form of the probability density of the diffuse reflection coefficient for the corresponding pigmented lesions. We propose a noninvasive technique for differentiating between malignant and benign tumors, based on measuring the diffuse reflection coefficient for a specific patient and comparing the value obtained with a pre-set threshold. If the experimental result is below the threshold, then it is concluded that the person has melanoma; otherwise, no melanoma is present. As an example, we consider the wavelength 870 nm. We determine the risk of malignant transformation of a nevus (its transition to melanoma) for different measured diffuse reflection coefficients. We have studied the errors in the method, its operating characteristics and probability characteristics as the threshold diffuse reflection coefficient is varied. We find that the diagnostic confidence, sensitivity, specificity, and effectiveness (accuracy) parameters are maximum (>0.82) for a threshold of 0.45-0.47. The operating characteristics for the proposed technique exceed the corresponding parameters for other familiar optical approaches to melanoma diagnosis. Its distinguishing feature is operation at only one wavelength, and consequently implementation of the experimental technique is simplified and made less expensive.
Starting Page	261
Ending Page	270
Page Count	10
File Format	PDF
ISSN	00219037
Journal	Journal of Applied Spectroscopy
Volume Number	83
Issue Number	2
e-ISSN	15738647
Language	English
Publisher	Springer US
Publisher Date	2016-05-10
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	melanoma nevus diffuse reflection coefficient spectrophotometry noninvasive diagnosis Atomic/Molecular Structure and Spectra Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Condensed Matter Physics

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