NDLI: Macrocystis angustifolia is a potential source of enzyme inhibitors linked to type 2 diabetes and dementia

Content Provider	Springer Nature Link
Author	Rengasamy, Kannan R. R. Aderogba, Mutalib A. Amoo, Stephen O. Stirk, Wendy A. Van Staden, Johannes
Copyright Year	2013
Abstract	In continuation of the screening of South African seaweeds to identify potential candidates for the development of pharmaceutically active functional foods, we investigated the inhibitory effects of a crude 80 % methanol extract, solvent fractions and isolated compounds from the kelp Macrocystis angustifolia against enzymes involved in type 2 diabetes and dementia. Repeated column fractionation of the ethyl acetate fraction of the crude extract of M. angustifolia afforded two phenol derivatives identified by spectroscopic analyses (1D and 2D NMR): 4-(2-hydroxyethyl)phenol (tyrosol) (1) and 4-(1,2-dihydroxyethyl)phenol (2). These compounds were isolated from a marine alga for the first time. The ethyl acetate (IC$_{50}$ = 14.08 ± 1.21 μg mL$^{−1}$) and butanol (IC$_{50}$ = 77.94 ± 11.69 μg mL$^{−1}$) fractions exhibited potent inhibition against α-glucosidase and acetylcholinesterase (AChE) enzymes, respectively. Tyrosol (1) and its derivative, 4-(1,2-dihydroxyethyl)phenol (2), showed potent inhibition against both α-glucosidase and AChE enzymes. Based on in silico evaluation, these two compounds are anticipated to possess sufficient oral bioavailability in accordance to the Lipinski Rule of Five without any toxicity risk. Natural α-glucosidase and AChE inhibitors from M. angustifolia offer a novel approach to control type 2 diabetes and dementia.
Starting Page	1557
Ending Page	1563
Page Count	7
File Format	PDF
ISSN	09218971
Journal	Journal of Applied Phycology
Volume Number	26
Issue Number	3
e-ISSN	15735176
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-10-10
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	4-(1,2-Dihydroxyethyl)phenol Acetylcholinesterase α-Glucosidase Drug-likeness Lipinski Rule of Five Tyrosol Plant Sciences Freshwater & Marine Ecology Plant Physiology Ecology
Content Type	Text
Resource Type	Article
Subject	Plant Science Aquatic Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Antidiabetic studies of Chaetomorpha antennina extract using experimental models

Testing sustainable management in Northern Chile: harvesting Macrocystis pyrifera (Phaeophyceae, Laminariales). A case study

Production of Macrocystis pyrifera (Laminariales; Phaeophyceae) in northern Chile on spore-based culture

Bioeconomic analysis of giant kelp Macrocystis pyrifera cultivation (Laminariales; Phaeophyceae) in northern Chile

Macrocystis mariculture in Chile: growth performance of heterosis genotype constructs under field conditions

Anti-diabetic potential of selected Malaysian seaweeds

Repopulation techniques for Macrocystis integrifolia (Phaeophyceae: Laminariales) in Atacama, Chile

Factors correlating with deterioration of giant kelp Macrocystis pyrifera (Laminariales, Heterokontophyta) in an aquarium setting

Plant growth promoting activity of seaweed liquid extracts produced from Macrocystis pyrifera under different pH and temperature conditions

Macrocystis angustifolia is a potential source of enzyme inhibitors linked to type 2 diabetes and dementia

Similar Documents

Antidiabetic studies of Chaetomorpha antennina extract using experimental models

Testing sustainable management in Northern Chile: harvesting Macrocystis pyrifera (Phaeophyceae, Laminariales). A case study

Production of Macrocystis pyrifera (Laminariales; Phaeophyceae) in northern Chile on spore-based culture

Bioeconomic analysis of giant kelp Macrocystis pyrifera cultivation (Laminariales; Phaeophyceae) in northern Chile

Macrocystis mariculture in Chile: growth performance of heterosis genotype constructs under field conditions

Anti-diabetic potential of selected Malaysian seaweeds

Repopulation techniques for Macrocystis integrifolia (Phaeophyceae: Laminariales) in Atacama, Chile

Factors correlating with deterioration of giant kelp Macrocystis pyrifera (Laminariales, Heterokontophyta) in an aquarium setting

Plant growth promoting activity of seaweed liquid extracts produced from Macrocystis pyrifera under different pH and temperature conditions

Macrocystis angustifolia is a potential source of enzyme inhibitors linked to type 2 diabetes and dementia