NDLI: Cannabinoid Receptor Type 2, but not Type 1, is Up-Regulated in Peripheral Blood Mononuclear Cells of Children Affected by Autistic Disorders

Content Provider	Springer Nature Link
Author	Siniscalco, Dario Sapone, Anna Giorda, Catia Cirillo, Alessandra Magistris, Laura Rossi, Francesco Fasa, Alessio Bradstreet, James Jeffrey Maione, Sabati Antonucci, Nicola
Copyright Year	2013
Abstract	Autistic disorders (ADs) are heterogeneous neurodevelopmental disorders arised by the interaction of genes and environmental factors. Dysfunctions in social interaction and communication skills, repetitive and stereotypic verbal and non-verbal behaviours are common features of ADs. There are no defined mechanisms of pathogenesis, rendering curative therapy very difficult. Indeed, the treatments for autism presently available can be divided into behavioural, nutritional and medical approaches, although no defined standard approach exists. Autistic children display immune system dysregulation and show an altered immune response of peripheral blood mononuclear cells (PBMCs). In this study, we investigated the involvement of cannabinoid system in PBMCs from autistic children compared to age-matched normal healthy developing controls (age ranging 3–9 years; mean age: 6.06 ± 1.52 vs. 6.14 ± 1.39 in autistic children and healthy subjects, respectively). The mRNA level for cannabinoid receptor type 2 (CB2) was significantly increased in AD-PBMCs as compared to healthy subjects (mean ± SE of arbitrary units: 0.34 ± 0.03 vs. 0.23 ± 0.02 in autistic children and healthy subjects, respectively), whereas CB1 and fatty acid amide hydrolase mRNA levels were unchanged. mRNA levels of N-acylphosphatidylethanolamine-hydrolyzing phospholipase D gene were slightly decreased. Protein levels of CB-2 were also significantly increased in autistic children (mean ± SE of arbitrary units: 33.5 ± 1.32 vs. 6.70 ± 1.25 in autistic children and healthy subjects, respectively). Our data indicate CB2 receptor as potential therapeutic target for the pharmacological management of the autism care.
Starting Page	2686
Ending Page	2695
Page Count	10
File Format	PDF
ISSN	01623257
Journal	Journal of Autism and Developmental Disorders
Volume Number	43
Issue Number	11
e-ISSN	15733432
Language	English
Publisher	Springer US
Publisher Date	2013-04-13
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Autistic disorders Cannabinoid system Gene expression PBMCs Child and School Psychology Pediatrics Neurosciences Public Health
Content Type	Text
Resource Type	Article
Subject	Developmental and Educational Psychology

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