NDLI: Response Inhibition and ADHD Traits: Correlates and Heritability in a Community Sample

Content Provider	Springer Nature Link
Author	Crosbie, J. Arld, P. Paterson, A. Swanson, J. Dupuis, A. Li, X. Shan, J. Goodale, T. Tam, C. Strug, L. J. Schachar, R. J.
Copyright Year	2013
Abstract	Endophenotypes or intermediate phenotypes are of great interest in neuropsychiatric genetics because of their potential for facilitating gene discovery. We evaluated response inhibition, latency and variability measures derived from the stop task as endophenotypes of ADHD by testing whether they were related to ADHD traits in the general population, heritable and shared genetic risk with ADHD traits. Participants were 16,099 children and adolescents, ages 6 to 18 years who visited a local science center. We measured ADHD traits using the Strengths and Weaknesses of ADHD-symptoms and Normal-Behavior (SWAN) rating scale and performance on the stop signal task (SST)—response inhibition (SSRT), response latency (GoRT), and response variability (GoRTSD). Regression analysis was used to assess the relationship of cognitive measures and ADHD traits while controlling for family, age, sex, ethnicity, socioeconomic status and treatment status. Heritability of ADHD and cognitive traits was estimated using SOLAR in 7,483 siblings from 3,507 families that included multiple siblings. Bivariate relationships between pairs of variables were examined. Individuals with greater ADHD trait scores had worse response inhibition, slower response latency, and greater variability. Younger participants and girls had inferior performance although the gender effects were minimal and evident in youngest participants. Inhibition, latency, variability, total ADHD traits, inattention and hyperactivity-impulsivity scores were significantly heritable. ADHD traits and inhibition, but not latency or variability were coheritable. In the largest study in the general population, we found support for the validity of response inhibition as an endophenotype of ADHD.
Starting Page	497
Ending Page	507
Page Count	11
File Format	PDF
ISSN	00910627
Journal	Journal of Abnormal Child Psychology
Volume Number	41
Issue Number	3
e-ISSN	15732835
Language	English
Publisher	Springer US
Publisher Date	2013-01-13
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	ADHD Stop signal task General population Endophenotype Heritability Child and School Psychology
Content Type	Text
Resource Type	Article
Subject	Developmental and Educational Psychology Psychiatry and Mental Health

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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Response Inhibition and ADHD Traits: Correlates and Heritability in a Community Sample

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