NDLI: Human nigral and liver iron – comparison by Mössbauer spectroscopy, electron microscopy and ELISA

Content Provider	Springer Nature Link
Author	Galazka Friedman, J. Bauminger, E. R. Friedman, A. Koziorowski, D. Szlachta, K.
Copyright Year	2006
Abstract	The properties of iron present in human liver and human substantia nigra (SN) were compared. Mössbauer measurements have shown that iron is present in similar concentrations in SN and in the liver, mainly as ferritin-like iron. The size of the iron cores of ferritin, as obtained from electron microscopy, is much smaller in SN (3.6 ± 0.4 nm) than in liver (5.7 ± 0.5 nm). The small size in SN is in agreement with the low blocking temperature (about 10 K), determined by temperature dependent Mössbauer studies on whole tissues. ELISA studies have shown differences between SN and liver in the structures of the protein shells of ferritin. The H/L ratio (concentration of heavy to light chains) in liver is 0.40 ± 0.02, while in SN it is 4.3 ± 0.3. Another possible iron binding compound in SN is neuromelanin (NM). Mössbauer studies of neuromelanin, isolated from 22 SNs, demonstrated that this iron is superparamagnetic. The blocking temperature found for this neuromelanin iron is however much higher than that for ferritin.
Starting Page	285
Ending Page	288
Page Count	4
File Format	PDF
ISSN	03043843
Journal	Hyperfine Interactions
Volume Number	165
Issue Number	1-4
e-ISSN	15729540
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2006-10-26
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	iron ferritin human liver substantia nigra Mössbauer spectroscopy electron microscopy ELISA Surfaces and Interfaces, Thin Films Condensed Matter Atoms, Molecules, Clusters and Plasmas Nuclear Physics, Heavy Ions, Hadrons
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Atomic and Molecular Physics, and Optics Physical and Theoretical Chemistry Condensed Matter Physics

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