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Proteolytic signaling mechanisms in skeletal muscles in patients with alcohol-induced muscle disease

Content Provider	Springer Nature Link
Author	Shenkman, B. S. Lomosova, Y. N. Lysenko, E. A. Kazantseva, Y. V. Zivyeva, O. E. Yakh, N. N.
Copyright Year	2013
Abstract	Chronic alcoholic myopathy is one of the most numerous and profound manifestations of chronic alcohol intoxication. This disease is characterized by the pronounced atrophy of the locomotor muscles, which involves fibers expressing predominantly type II (fast) myosin isoforms. In early experiments with rats receiving alcohol and studies of patients, the impairment of the anabolic intracellular signaling pathways and decrease in protein synthesis rate were shown. We were the first to analyze the signaling pathways involved in the pathogenesis of alcoholic myopathy with different fiber atrophy levels. At the early stages of pathogenesis, we observed also a sufficient increase in mRNA of E3 ubiquitin ligases. However, the ubiquitinylation level was not altered in patients as compared to the control subjects. This phenomenon could be related to an increased expression of heat shock proteins known for their protective action.
Starting Page	545
Ending Page	550
Page Count	6
File Format	PDF
ISSN	03621197
Journal	Human Physiology
Volume Number	39
Issue Number	5
e-ISSN	16083164
Language	English
Publisher	Springer US
Publisher Date	2013-10-11
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	skeletal muscle alcohol intoxication atrophy of muscle fibers alcohol-induced muscle damage proteolysis E3 ubiquitin ligases heat shock proteins Life Sciences Human Physiology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical)

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Ubiquitin Ligases at the Heart of Skeletal Muscle Atrophy Control

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Proteolytic signaling mechanisms in skeletal muscles in patients with alcohol-induced muscle disease

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