NDLI: Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3α signaling pathway in C2C12 myotubes and mice.

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Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3α signaling pathway in C2C12 myotubes and mice.

Content Provider	Europe PMC
Author	Chen, Li Chen, Linlin Wan, Lili Huo, Yan Huang, Jinlu Li, Jie Lu, Jin Xin, Bo Yang, Quanjun Guo, Cheng
Copyright Year	2019
Abstract	Skeletal muscle wasting is a feature of cancer cachexia that increases patient morbidity and mortality. Matrine, the main bioactive component of Sophora flavescens, has been approved for the prevention and therapy of cancer cachexia in China. However, to the best of our knowledge, its mechanism in improving muscle wasting remains unknown. The present study demonstrated that matrine increases muscle fiber size and muscle mass in an in vivo CT26 colon adenocarcinoma cachexia mouse model. Concurrently, other cachexia symptoms, including body and organ weight loss, were alleviated. In in vitro experiments, matrine substantially improved C2C12 myoblast differentiation with or without dexamethasone treatment. In addition, matrine reduced C2C12 myotube atrophy and apoptosis induced by dexamethasone, tumor necrosis factor α and conditioned medium. Two E3 ubiquitin ligases, muscle RING-finger containing protein-1 and muscle atrophy Fbox protein, which are specifically expressed in wasting skeletal muscle, were also significantly downregulated (P<0.05) by matrine both in C2C12 myotubes and skeletal muscle. Furthermore, matrine increased the phosphorylation of Akt, mTOR and FoxO3α in the atrophying C2C12 myotube induced by dexamethasone. In conclusion, matrine can alleviate muscle atrophy and improve myoblast differentiation possibly by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3α signaling pathway.
ISSN	1021335X
Journal	Oncology Reports
Volume Number	42
PubMed Central reference number	PMC6610044
Issue Number	2
PubMed reference number	31233199
e-ISSN	17912431
DOI	10.3892/or.2019.7205
Language	English
Publisher	D.A. Spandidos
Publisher Date	2019-06-19
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Chen et al.
Subject Keyword	cancer cachexia skeletal muscle matrine; E3 ubiquitin ligase Akt/mTOR/FoxO3α
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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