NDLI: Hyperlipidemia induced by high-fat diet enhances dentin formation and delays dentin mineralization in mouse incisor

Content Provider	Springer Nature Link
Author	Ye, Xin Zhang, Jin Yang, Pishan
Copyright Year	2016
Abstract	Dyslipidemia has become a serious health problem in children and adolescents worldwide for its high prevalence. Since hard tissues of permanent teeth form mainly during this period and lipids are actively involved in tooth development, the effects of hyperlipidemia on dental tissue formation and mineralization need to be illustrated. In this study, hyperlipidemia model was established in mice fed with high-fat diet (HFD). Micro-CT and histomorphological analyses were performed on the mandibular bones to assess the morphological changes of the mandibular incisor and first molar. After 4 weeks of HFD feeding, mice had significantly elevated serum lipid levels compared with mice fed with control diet. After 8 weeks, the mandibular incisor presented significantly increased dentin thickness and decreased diameter of pulp cavity in HFD-fed mice compared with control diet-fed mice, while its gross morphology and enamel thickness were not altered. In the mandibular first molar, dentin thickness of root did not show difference between the two groups. Histological section showed that mandibular incisor of HFD-fed mice manifested a wider predentin region and a lower mineral apposition rate compared with that of the control mice. In conclusion, hyperlipidemia induced by HFD feeding enhances dentin formation and delays dentin mineralization in the developing mouse incisor.
Starting Page	467
Ending Page	474
Page Count	8
File Format	PDF
ISSN	15672379
Journal	The Histochemical Journal
Volume Number	47
Issue Number	5
e-ISSN	15672387
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-08-24
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hyperlipidemia Dyslipidemia Tooth development Dentinogenesis Dentin mineralization Cell Biology Biomedicine general Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology Histology

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