NDLI: Immunohistochemical localization of LIM mineralization protein 1 during mouse molar development

Content Provider	Springer Nature Link
Author	Fang, Pingjuan Wang, Xiaoying Zhang, Lu Yuan, Guohua Chen, Zhi Zhang, Qi
Copyright Year	2010
Abstract	LIM mineralization protein 1 (LMP-1) is an essential positive regulator of osteoblast differentiation, maturation and bone formation. Our previous investigations on the distribution of LMP-1 in mature human teeth indicated that LMP-1 might play a role in the odontoblast differentiation and dentin matrix mineralization. The aim of the present study was to use immunohistochemistry to determine the expression of LMP-1 during tooth development in mouse molars. In embryonic and postnatal Kunming mice, LMP-1 protein was expressed during molar development, but the expression levels and patterns differed at various developmental stages. At embryonic day 13.5 (E13.5), LMP-1 was found in the enamel organ. At E14.5, LMP-1 was detected in the entire enamel organ and in the underlying mesenchyme. At E16.5, LMP-1 was observed in the inner and outer enamel epithelium and the stratum intermedium. The expression also converged at the cusps in the dental papilla. At E18.5 and postnatal day 2.5 (P2.5), LMP-1 was restricted to the stratum intermedium, in differentiating dental papilla cells at cusps, while it disappeared in terminal differentiated ameloblasts and odontoblasts. At P13.5, no positive staining was detected in the odontoblasts or in the dental pulp cells. Therefore, LMP-1 showed spatiotemporal expression patterns during molar development and might participate in molar crown morphogenesis and odontoblast differentiation at late molar development.
Starting Page	199
Ending Page	203
Page Count	5
File Format	PDF
ISSN	15672379
Journal	The Histochemical Journal
Volume Number	41
Issue Number	4-5
e-ISSN	15672387
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-08-13
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Tooth development Morphogenesis Differentiation LIM mineralization protein 1 Developmental Biology Cell Biology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology Histology

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