NDLI: Analysis of Vitamin D-receptor (VDR) and Retinoid X-receptor α in Breast Cancer

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The Histochemical Journal : Volume 33

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The Histochemical Journal : Volume 29

Analysis of Vitamin D-receptor (VDR) and Retinoid X-receptor α in Breast Cancer

Content Provider	Springer Nature Link
Author	Friedrich, Michael Axt Fliedner, Roland Villena Heinsen, Carlos Tilgen, Wolfgang Schmidt, Werner Reichrath, Jörg
Copyright Year	2002
Abstract	The expression of vitamin D-receptor (VDR) and retinoid X-receptor α (RXR-α) has been analysed immunohistochemically in benign (n = 62 and n = 5 respectively) and malignant (n = 228 and n = 15 respectively) breast tissue samples using a monoclonal antibody 9A7γ against VDR and a polyclonal antibody against RXR-α. A recently developed immunoreactive scoring method (IRS) was employed. The expression of VDR was detected at the RNA-level using the reverse transcriptase–polymerase chain reaction. A statistically significant higher expression of VDR at the protein level was seen in breast cancer compared with benign breast tissue, whereas at the mRNA level no visible differences in the expression of VDR were found. A higher expression of RXR-α was seen in breast cancer compared with benign breast tissue. Our findings indicate that breast tissue may be a new target organ for therapeutically applied vitamin D and retinoid analogues. VDR and RXR-α are upregulated at the protein level in breast carcinomas as compared to normal breast tissue, indicating a possibly increased sensitivity to therapeutically applied vitamin D analogues. New vitamin D analogues exerting less calcemic side effects may be promising new drugs for the treatment or chemoprevention of breast carcinomas as well as of precancerous breast lesions. Combination therapies of vitamin D and retinoid analogues with fewer side effects seen promising for the treatment of breast cancer.
Starting Page	35
Ending Page	40
Page Count	6
File Format	PDF
ISSN	00182214
Journal	The Histochemical Journal
Volume Number	34
Issue Number	1-2
e-ISSN	15736865
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2002-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Cell Biology Biomedicine general Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Anatomy Cell Biology

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