NDLI: Tenascin, E-cadherin and P2X Calcium Channel Receptor Expression is Increased during Rat Blastocyst Implantation

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The Histochemical Journal : Volume 33

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The Histochemical Journal : Volume 30

The Histochemical Journal : Volume 29

Tenascin, E-cadherin and P2X Calcium Channel Receptor Expression is Increased during Rat Blastocyst Implantation

Content Provider	Springer Nature Link
Author	Slater, M. Murphy, C.R. Barden, J.A.
Copyright Year	2002
Abstract	The calcium-activated cell-adhesion proteins tenascin, E-cadherin and the purinergic (P2X) calcium channel receptors are expressed in an identical spatial and temporal pattern in uterine epithelium in the rat during implantation. On Day 1 of pregnancy (estrous), a diffuse cytoplasmic and specific basement membrane label for each of the proteins was observed throughout the uterine epithelium. On Day 3 of pregnancy, a specific and prominent lateral plasma membrane label for each protein was seen. At the time of implantation on Day 6, an additional and significant increase in the label for each was observed on the apical epithelium. At this time, the label for tenascin in the apical epithelium was increased 2.1-fold (p < 0.0004), that of E-cadherin was increased 2.5-fold (p < 0.0001) and the P2X receptor label was increased 2.0-fold (p < 0.0001). These observations suggest a major role for the calcium-activated adhesion proteins tenascin and E-cadherin in attachment and implantation, with ionic calcium for protein activation possibly provided by the P2X calcium channels. These events occur along the entire length of the uterine epithelium in preparation for blastocyst adhesion.
Starting Page	13
Ending Page	19
Page Count	7
File Format	PDF
ISSN	00182214
Journal	The Histochemical Journal
Volume Number	34
Issue Number	1-2
e-ISSN	15736865
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2002-01-01
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Cell Biology Biomedicine general Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Anatomy Cell Biology

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