NDLI: Transformer 2β (Tra2β/SFRS10) positively regulates the progression of NSCLC via promoting cell proliferation

Content Provider	Springer Nature Link
Author	Ji, Lili Ni, Tingting Shen, Yanbo Xue, Qun Liu, Yifei Chen, Buyou Cui, Xuefan Lv, Liting Yu, Xiafei Cui, Yuan Lu, Xiaoning Chen, Jie Mao, Guoxin Wang, Yuchan
Copyright Year	2014
Abstract	Transformer 2β (Tra2β), a member of the serine/arginine-rich-like protein family, is an important RNA-binding protein involved in alternative splice. Deregulation of Tra2β has been observed in several cancers. However, the detailed role of Tra2β in non-small cell lung cancer (NSCLC) has not been elucidated. In this study, the contribution of Tra2β to NSCLC development was investigated. On histological level, the expression of Tra2β was determined by Western and immunohistochemistry assays. It demonstrated that Tra2β was expressed higher in NSCLC tumor tissues compared with adjacent non-tumor tissues. In addition to confirm the association of Tra2β expression with histological differentiation and clinical stage (p < 0.05), we also confirmed significant positive correlation between the expression level of Tra2β and that of Ki67 (p < 0.05, r = 0.446) by Spearman rank correlation test. Moreover, high expression of Tra2β predicted poor prognosis by Kaplan–Meier survival analysis. And Tra2β among with other clinicopathologic variables was an independent prognostic indicator for patients’ overall survival by multivariate analysis. On cellular level, Tra2β expression was demonstrated to promote proliferation of NSCLC cells through a series of assays, including serum starvation and release assay, Western blot assay and flow cytometry analysis. Moreover, knockdown of Tra2β was confirmed to inhibit proliferation and to induce apoptosis of NSCLC cells through flow cytometry analysis, western analysis, cell counting kit-8 assay and Tunnel assay. Our results indicated that Tra2β was involved in the tumorigenesis of NSCLC and might be a potential therapeutic target of NSCLC.
Starting Page	573
Ending Page	582
Page Count	10
File Format	PDF
ISSN	15672379
Journal	The Histochemical Journal
Volume Number	45
Issue Number	5
e-ISSN	15672387
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-06-21
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	NSCLC Tra2β Prognosis Proliferation Apoptosis Cell Biology Biomedicine general Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology Histology

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