NDLI: Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP

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Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP

Content Provider	Springer Nature Link
Author	Almendingen, Kari Larsen, Laila N. Fausa, Olav Bratlie, Jorunn Høstmark, Arne T. Aabakken, Lars
Copyright Year	2010
Abstract	Familial adenomatous polyposis (FAP) provides a model for sporadic colorectal cancer development. Cyclooxygenase (COX) inhibition may ameliorate polyp development, but rofecoxib was withdrawn due to cardiovascular side effects. Although this selective COX-2 inhibitor, like diet, may alter the fatty acid and eicosanoid pattern, data on the potential alteration in tissues after use, are scarce. The aims were to study if rofecoxib might influence the fatty acid distribution in serum phospholipids and duodenal lesions, mRNA for COX-1 and COX-2 in leucocytes and duodenal lesions, and finally plasma levels of PGE2 in a randomized, double-blind, placebo controlled study (n = 38). Significant reductions were found for essential fatty acid index both in serum phospholipids (P = 0.01, 95% CI = −0.9; −0.1), and in duodenal lesions (P = 0.04, 95 CI % = −0.9; −0.1) after treatment. No treatment effects were found on the COX mRNA expression, or in the plasma PGE2 levels. Dietary AA/EPA ratio was inversely associated with all the indicators of EFA status (all P < 0.01). These findings suggest that the effects of COX chemoprevention should be further investigated in FAP and that dietary needs should be included in the treatment of FAP.
Starting Page	571
Ending Page	580
Page Count	10
File Format	PDF
ISSN	13899600
Journal	Familial Cancer
Volume Number	9
Issue Number	4
e-ISSN	15737292
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-07-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Familial adenomatous polyposis Cyclooxygenase Diet Fatty acids Biomedicine general Epidemiology Human Genetics Cancer Research
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research Genetics (clinical) Oncology

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Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP

Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP

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Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP

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Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP

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Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP