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MHC influences infection with parasites and winter survival in the root vole Microtus oeconomus

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MHC influences infection with parasites and winter survival in the root vole Microtus oeconomus

Content Provider	Springer Nature Link
Author	Kloch, Agnieszka Baran, Kamil Buczek, Mateusz Konarzewski, Marek Radwan, Jacek
Copyright Year	2012
Abstract	Selective pressure from parasites is thought to maintain the polymorphism of major histocompatibility complex (MHC) genes. Although a number of studies have shown a relationship between the MHC and parasitic infections, the fitness consequences of such associations are less well documented. In the present paper, we characterised the variation in exon 2 of MHC class II DRB gene in the root vole and examined the effects of that gene on parasite prevalence and winter survival. We identified 18 unique exon 2 sequences, which translated into 10 unique amino acid sequences. Phylogenetic analysis revealed the presence of three distinct clusters, and allele distributions among these individuals suggested that the clusters correspond to three different loci. Although the rate of synonymous substitutions (dS) exceeded the rate of nonsynonymous substitutions (dN) across sequences, implying purifying selection, dN was significantly elevated at antigen-binding sites, suggesting that these sites could be under positive selection. Screening for parasites revealed a moderate prevalence of infection with gastrointestinal parasites (24 % infected), but a high infection rate for blood parasites (56 % infected). Infection with the blood parasite Babesia ssp. decreased survival almost twofold (25.7 vs. 13.9 %). Animals possessing the amino acid sequence AA08 survived better than others (44.9 vs. 22 %), and they were infected with Babesia ssp. less often (13.9 vs 25.7 %). In contrast, individuals carrying allele AA05 were infected more often (31.7 vs. 15.3 %). Heterozygosity at one of the putative loci was associated with a lower probability of infection with Babesia ssp., but at the other locus, the association was reversed. The unexpected latter result could be at least partly explained by the increased frequency of the susceptible allele AA*05 among heterozygotes. Overall, we demonstrate that infection with Babesia ssp. is a strong predictor of winter survival and that MHC genes are important predictors of infection status as well as survival in the root vole.
Starting Page	635
Ending Page	653
Page Count	19
File Format	PDF
ISSN	02697653
Journal	Evolutionary Ecology
Volume Number	27
Issue Number	3
e-ISSN	15738477
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-10-10
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	MHC Microtus oeconomus Survival Infection Parasites Babesia Next-generation sequencing Evolutionary Biology Plant Sciences Human Genetics
Content Type	Text
Resource Type	Article
Subject	Ecology, Evolution, Behavior and Systematics

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MHC influences infection with parasites and winter survival in the root vole Microtus oeconomus

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MHC influences infection with parasites and winter survival in the root vole Microtus oeconomus