NDLI: Interaction effects of lead on bioavailability and pharmacokinetics of arsenic in the rat

Content Provider	Springer Nature Link
Author	Diacomalis, Violet ller, Barry N. Ng, Jack C.
Copyright Year	2013
Abstract	Arsenic (As) and lead (Pb) are common contaminants found in mine waste materials. For an evidence-based risk assessment, it is important to better understand the potential interaction of mixed contaminants; and this interaction study was investigated in an in vivo rat model. Following co-administration of a fixed dose of AsV as in sodium arsenate and different doses of Pb as lead acetate to Sprague–Dawley rats, blood arsenic concentration and bioavailability decreased. A decrease in As blood concentration when lead was co-administered was observed with increasing lead doses. Pharmacokinetic parameters for As in the blood showed faster absorption and elimination of this metalloid in the presence of Pb. The elimination half-life of As decreased from 67 days in As solo group to 27–30 with doses of Pb. Bioavailability of As was also decreased by 30–43 % in the presence of Pb. Decreased urinary excretion of Pb and tissue accumulation were also observed. It indicates lower absorption of As when co-administered with Pb. A probable explanation for these findings is that As co-administration with Pb could have resulted in the formation of less soluble lead arsenate. However, such an interaction between As and Pb could only explain about one-third of the variation when real mine waste materials containing both of these elements were administered to rats. This suggests that other effects from physical and chemical parameters could contribute to the bioavailability of arsenic in complex real environmental samples.
Starting Page	757
Ending Page	766
Page Count	10
File Format	PDF
ISSN	02694042
Journal	Environmental Geochemistry and Health
Volume Number	35
Issue Number	6
e-ISSN	15732983
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-06-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Arsenic Lead Mine waste Bioavailability Mixed contaminants Pharmacokinetic parameters Interaction effect Environmental Health Geochemistry Terrestrial Pollution Soil Science & Conservation Environmental Chemistry Public Health
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Medicine Geochemistry and Petrology Environmental Engineering Water Science and Technology

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