NDLI: Acute, subacute, and subchronic exposure to 2A-DNT (2-amino-4,6-dinitrotoluene) in the northern bobwhite (Colinus virginianus)

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Acute, subacute, and subchronic exposure to 2A-DNT (2-amino-4,6-dinitrotoluene) in the northern bobwhite (Colinus virginianus)

Content Provider	Springer Nature Link
Author	Quinn, Michael J. McFarland, Craig A. LaFiandra, Emily M. Bazar, Matthew A. Johnson, Mark S.
Copyright Year	2010
Abstract	2-Amino-4,6-dinitrotoluene (2A-DNT) is a metabolite of the explosive 2,4,6-trinitrotoluene (TNT) which is present in the soil at numerous U.S. Army installations as the result of TNT manufacture or training activities. Although many avian species are known to inhabit areas where 2A-DNT has been found in the environment, no published studies of the effects of 2A-DNT exposure in birds are available. In this study, we conducted an evaluation of the oral toxicity of 2A-DNT in a representative ground foraging species of management concern, the northern bobwhite (Colinus virginianus). Subacute (14 days) and subchronic (60 days) oral gavage exposure studies were conducted following determination of the median acute lethal dose (LD50 = 1167 mg/kg). In the subacute study, survival occurred at 50 mg/kg/day. This helped to determine dose groups for the subchronic study: 0, 0.5, 3, 14, and 30 mg 2A-DNT/kg body weight-d in corn oil. The lowest observed adverse effects level (LOAEL) was determined to be 14 mg/kg/day based on mortality, and the no observed adverse effects level (NOAEL) was determined to be 3 mg/kg/day based on lack of effects at this exposure level.
Starting Page	945
Ending Page	952
Page Count	8
File Format	PDF
ISSN	09639292
Journal	Ecotoxicology
Volume Number	19
Issue Number	5
e-ISSN	15733017
Language	English
Publisher	Springer US
Publisher Date	2010-03-09
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	2A-DNT 2-Amino-4,6-dinitrotoluene Northern bobwhite Explosive TNT Environmental Management Ecology Environment Ecotoxicology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Management, Monitoring, Policy and Law

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Acute, subacute, and subchronic exposure to 2A-DNT (2-amino-4,6-dinitrotoluene) in the northern bobwhite (Colinus virginianus).

Systems toxicology identifies mechanistic impacts of 2-amino-4,6-dinitrotoluene (2A-DNT) exposure in Northern Bobwhite

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Systems toxicology identifies mechanistic impacts of 2-amino-4,6-dinitrotoluene (2A-DNT) exposure in Northern Bobwhite

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Aspects of northern bobwhite ecology on south Florida US pastureland

Acute, subacute, and subchronic exposure to 2A-DNT (2-amino-4,6-dinitrotoluene) in the northern bobwhite (Colinus virginianus)

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