NDLI: Limited diversity associated with duplicated class II MHC-DRB genes in the red squirrel population in the United Kingdom compared with continental Europe

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Limited diversity associated with duplicated class II MHC-DRB genes in the red squirrel population in the United Kingdom compared with continental Europe

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Limited diversity associated with duplicated class II MHC-DRB genes in the red squirrel population in the United Kingdom compared with continental Europe

Content Provider	Springer Nature Link
Author	Ballingall, Keith T. McIntyre, Angeline Lin, Zhenzhen Timmerman, Naomi Matthysen, Erik Lurz, Peter W.W. Melville, Lynsey Wallace, Amy Meredith, Anna L. Romeo, Claudia Wauters, Lucas A. Sainsbury, Anthony W. McInnes, Colin J.
Copyright Year	2016
Abstract	The red squirrel (Sciurus vulgaris) population in the United Kingdom has declined over the last century and is now on the UK endangered species list. This is the result of competition from the eastern grey squirrel (S. carolinensis) which was introduced in the 19th century. However, recent evidence suggests that the rate of population decline is enhanced by squirrelpox disease, caused by a viral infection carried asymptomatically by grey squirrels but to which red squirrels are highly susceptible. Population genetic diversity provides some resilience to rapidly evolving or exotic pathogens. There is currently no data on genetic diversity of extant UK squirrel populations with respect to genes involved in disease resistance. Diversity is highest at loci involved in the immune response including genes clustered within the major histocompatibility complex (MHC). Using the class II DRB locus as a marker for diversity across the MHC region we genotyped 110 red squirrels from locations in the UK and continental Europe. Twenty-four Scvu-DRB alleles at two functional loci; Scvu-DRB1 and Scvu-DRB2, were identified. High levels of diversity were identified at both loci in the continental populations. In contrast, no diversity was observed at the Scvu-DRB2 locus in the mainland UK population while a high level of homozygosity was observed at the Scvu-DRB1 locus. The red squirrel population in the UK appears to lack the extensive MHC diversity associated with continental populations, a feature which may have contributed to their rapid decline.
Starting Page	1171
Ending Page	1182
Page Count	12
File Format	PDF
ISSN	15660621
Journal	Conservation Genetics
Volume Number	17
Issue Number	5
e-ISSN	15729737
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-05-11
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Red squirrel MHC DRB Population UK Diversity Squirrelpox virus Disease Conservation Biology/Ecology Ecology Biodiversity Evolutionary Biology Plant Genetics & Genomics Animal Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics Ecology, Evolution, Behavior and Systematics

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