NDLI: Adhesion polypeptides are useful for the prevention of peritoneal dissemination of gastric cancer

Please wait, while we are loading the content...

A unique allogenic model of metastatic pheochromocytoma: PC12 rat pheochromocytoma xenografts to nude mice and establishment of metastases-derived PC12 variants

Time and dose dependency of the suppression of pulmonary metastases of rat mammary cancer by amiloride

Inhibition of VLA-4 and up-regulation of TIMP-1 expression in B16BL6 melanoma cells transfected with MHC class I genes

Pharmacological control of lung metastases of solid tumours by a novel ruthenium complex

Adhesion polypeptides are useful for the prevention of peritoneal dissemination of gastric cancer

Establishment of lymph node metastatic model for human gastric cancer in nude mice and analysis of factors associated with metastasis

Clinical & Experimental Metastasis : Volume 16, Issue 3, April 1998

Clinical & Experimental Metastasis : Volume 16, Issue 2, February 1998

Clinical & Experimental Metastasis : Volume 16, Issue 1, January 1998

Clinical & Experimental Metastasis : Volume 15

Adhesion polypeptides are useful for the prevention of peritoneal dissemination of gastric cancer

Content Provider	Springer Nature Link
Author	Matsuoka, Tasuku Hirakawa YS Chung, Kosei Yashiro, Masakazu Nishimura, Shigehiko Sawada, Tetsuji Saiki, Ikuo Sowa, Michio
Copyright Year	1998
Abstract	We examined the effect of adhesion polypeptides on the adhesion and invasiveness of gastric cancer cell lines. We previously reported the establishment of an extensively peritoneal-seeding cell line, OCUM-2MD3, from a poorly seeding human scirrhous gastric carcinoma cell line, OCUM-2M. Both 2β1 and α3β1 integrin expression was markedly increased on OCUM-2MD3 cells compared with OCUM-2M cells, and the ability of OCUM-2MD3 cells to bind to the extracellular matrix (ECM) was also significantly higher than that of OCUM-2M cells. The adhesion polypeptides, YIGSR and RGD, and two RGD derivatives significantly inhibited the adhesion of OCUM-2MD3 cells to the submesothelial ECM, while not inhibiting the adhesiveness of OCUM-2M cells and two well differentiated human gastric cell lines, MKN-28 and MKN-74. The YIGSR and RGD peptides also significantly inhibited the invasiveness of OCUM-2MD3 cells. The survival of nude mice with peritoneal dissemination given YIGSR sequenc e intraperitoneally was obviously longer than that of untreated mice. The survival of mice treated with RGD was also improved, and this effect was increased using the RGD derivatives, poly(CEMA-RGDS) and CM-chitin RGDS. These polypeptides appear to block the binding of integrins, which are expressed on OCUM-2MD3 cells, to the submesothelial ECM, and consequently inhibit peritoneal implantation. The peritoneal injection of adhe-sion polypeptides may be a new therapy against the dissemination of scirrhous gastric cancer, and may be useful for the prevention of dissemination in high-risk patients. © Rapid Science Ltd.
Starting Page	381
Ending Page	388
Page Count	8
File Format	PDF
ISSN	02620898
Journal	Clinical & Experimental Metastasis
Volume Number	16
Issue Number	4
e-ISSN	15737276
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	1998-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hematology Surgical Oncology Pathology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition

Adhesion molecules in peritoneal dissemination: function, prognostic relevance and therapeutic options

Smad interacting protein 1 (SIP1) is associated with peritoneal carcinomatosis in intestinal type gastric cancer

Inhibition of adhesion and proliferation of peritoneally disseminated tumor cells by pegylated catalase

The involvement of NK cell activation following intranasal administration of CpG DNA lipoplex in the prevention of pulmonary metastasis and peritoneal dissemination in mice

Personalized analysis of minimal residual cancer cells in peritoneal lavage fluid predicts peritoneal dissemination of gastric cancer

Are selectins involved in metastasis?

Is gastrointestinal dysfunction induced by gastric cancer peritoneal metastasis relevant to impairment of interstitial cells of Cajal?

Potentiation of cell invasion and matrix metalloproteinase production by α3β1 integrin-mediated adhesion of gastric carcinoma cells to laminin-5

Adhesion polypeptides are useful for the prevention of peritoneal dissemination of gastric cancer

Similar Documents

Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition

Adhesion molecules in peritoneal dissemination: function, prognostic relevance and therapeutic options

Smad interacting protein 1 (SIP1) is associated with peritoneal carcinomatosis in intestinal type gastric cancer

Inhibition of adhesion and proliferation of peritoneally disseminated tumor cells by pegylated catalase

The involvement of NK cell activation following intranasal administration of CpG DNA lipoplex in the prevention of pulmonary metastasis and peritoneal dissemination in mice

Personalized analysis of minimal residual cancer cells in peritoneal lavage fluid predicts peritoneal dissemination of gastric cancer

Are selectins involved in metastasis?

Is gastrointestinal dysfunction induced by gastric cancer peritoneal metastasis relevant to impairment of interstitial cells of Cajal?

Potentiation of cell invasion and matrix metalloproteinase production by α3β1 integrin-mediated adhesion of gastric carcinoma cells to laminin-5

Adhesion polypeptides are useful for the prevention of peritoneal dissemination of gastric cancer