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Clinical & Experimental Metastasis : Volume 16, Issue 3, April 1998

Clinical & Experimental Metastasis : Volume 16, Issue 2, February 1998

Clinical & Experimental Metastasis : Volume 16, Issue 1, January 1998

Clinical & Experimental Metastasis : Volume 15

Melanoma × macrophage hybrids with enhanced metastatic potential

Content Provider	Springer Nature Link
Author	Rachkovsky, Michael Sodi, Stefa Chakraborty, Ashok Avissar, Yael Bolognia, Jean Madison McNiff, Jennifer Platt, James Bermudes, David Pawelek, John
Copyright Year	1998
Abstract	Studies were conducted on the hypothesis that melanoma metastasis might be initiated through the gener-ation of hybrids comprised of cells of the primary tumor and tumor-infiltrating leukocytes. Fusion hybrids were generated in vitro between weakly metastatic Cloudman S91 mouse melanoma cells and normal mouse or human macrophages. Hybrids were implanted s.c. in the tail and mice were monitored for metastases. Controls included parental S91 cells, autologous S91 × S91 hybrids, and B16F10 melanoma cells. Of 35 hybrids tested, most were more aggressive than the parental melanoma cells, producing metastases sooner and in more mice. A striking characteristic was heterogeneity amongst hybrids, with some lines producing no metastases and others producing metastases in up to 80% of mice. With few exceptions, hybrids with the highest metastatic potential also had the highest basal melanin content whereas those with the lowest metastatic potential were basally amelanotic, as were t he parental melanoma cells. A spontaneous in vivo supermelanotic hybrid between an S91 tumor cell and DBA/2J host cell was one of the most metastatic lines. Hybrids with the highest metastatic potential also exhibited markedly higher chemotaxis to fibroblast-conditioned media. Histologically, the metastatic hybrids demonstrated vascular invasion and spread to distant organs similar to that of metastatic melanomas in mice and humans. Thus previous findings of enhanced metastasis in leukocyte × lymphoma hybrids can now be extended to include leukocyte × melanoma hybrids. Whether such hybridization is a natural cause of metastasis in vivo remains to be determined; however the fusion hybrids with genetically-matched parents described herein so closely resembled naturally- occurring metastatic melanoma cells that they could serve as useful new models for studies of this complex and deadly phenomenon. © Rapid Science Ltd.
Starting Page	299
Ending Page	312
Page Count	14
File Format	PDF
ISSN	02620898
Journal	Clinical & Experimental Metastasis
Volume Number	16
Issue Number	4
e-ISSN	15737276
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	1998-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hematology Surgical Oncology Pathology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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Melanoma × macrophage hybrids with enhanced metastatic potential

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