NDLI: High expression of Snail mRNA in blood from hepatocellular carcinoma patients with extra-hepatic metastasis

Content Provider	Springer Nature Link
Author	Min, Ae Lyoung Choi, Jong Young Woo, Hyun Young Kim, Jin Dong Kwon, Jung Hyun Bae, Si Hyun Yoon, Seung Kew Shin, Seung Hun Chung, Yeun Jun Jung, Chan Kwon
Copyright Year	2009
Abstract	The presence of circulating tumor cells (CTCs) in patients with hepatocellular carcinoma (HCC) suggests metastasis to extra-hepatic organs. Snail is a key regulator of epithelial mesenchymal transition, which is closely associated with tumor metastasis. The aim of this study was to investigate the presence of CTCs and evaluate the significance of Snail mRNA levels in peripheral blood of HCC patients with and without extra-hepatic metastasis. Sixty-six consecutive patients with HCC (30 without metastasis, 36 with metastasis) were prospectively enrolled, as were 30 with liver cirrhosis and 23 healthy subjects. CTCs were isolated by FACS using Ber-EP4 and anti-CD45 antibodies, and CTC identity confirmed by immunofluorescent cytokeratin staining. Snail mRNA levels were measured by quantitative real-time PCR of blood samples. CTCs, positive for pan-cytokeratin and Snail, were isolated from five HCC patients with metastasis. The mean amount of Snail mRNA in HCC with metastasis was 18.8-fold, 26.6-fold greater than HCC without metastasis, liver cirrhosis, respectively. When compared with healthy controls, the mean level of Snail mRNA in HCC without metastasis was 10.1-fold greater (P < 0.001). In six patients showing complete remission of HCC, Snail mRNA decreased to levels similar to those of healthy controls. This study suggests the possibility that circulating Snail mRNA levels may have been associated with extra-hepatic metastasis in HCC patients.
Starting Page	759
Ending Page	767
Page Count	9
File Format	PDF
ISSN	02620898
Journal	Clinical & Experimental Metastasis
Volume Number	26
Issue Number	7
e-ISSN	15737276
Language	English
Publisher	Springer Netherlands
Publisher Date	2009-06-16
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hepatocellular Carcinoma Circulating tumor cell Snail Metastasis Surgical Oncology Hematology Oncology Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Over-expression of integrin-linked kinase correlates with aberrant expression of Snail, E-cadherin and N-cadherin in oral squamous cell carcinoma: implications in tumor progression and metastasis

Prognosis of hepatocellular carcinoma patients with extrahepatic metastasis and the controllability of intrahepatic lesions

Sinusoidal tumor angiogenesis is a key component in hepatocellular carcinoma metastasis

Decreased expression of miR-126 correlates with metastatic recurrence of hepatocellular carcinoma

MTBP inhibits migration and metastasis of hepatocellular carcinoma

Bladder metastasis from renal cell carcinoma: retrospective analysis of 65 reported cases

Strong expression of chemokine receptor CXCR4 by renal cell carcinoma cells correlates with metastasis

FAK is involved in invasion and metastasis of hepatocellular carcinoma

Circulating tumor cell associated white blood cell cluster as a biomarker for metastasis and recurrence in hepatocellular carcinoma

High expression of Snail mRNA in blood from hepatocellular carcinoma patients with extra-hepatic metastasis

Similar Documents

Over-expression of integrin-linked kinase correlates with aberrant expression of Snail, E-cadherin and N-cadherin in oral squamous cell carcinoma: implications in tumor progression and metastasis

Prognosis of hepatocellular carcinoma patients with extrahepatic metastasis and the controllability of intrahepatic lesions

Sinusoidal tumor angiogenesis is a key component in hepatocellular carcinoma metastasis

Decreased expression of miR-126 correlates with metastatic recurrence of hepatocellular carcinoma

MTBP inhibits migration and metastasis of hepatocellular carcinoma

Bladder metastasis from renal cell carcinoma: retrospective analysis of 65 reported cases

Strong expression of chemokine receptor CXCR4 by renal cell carcinoma cells correlates with metastasis

FAK is involved in invasion and metastasis of hepatocellular carcinoma

Circulating tumor cell associated white blood cell cluster as a biomarker for metastasis and recurrence in hepatocellular carcinoma

High expression of Snail mRNA in blood from hepatocellular carcinoma patients with extra-hepatic metastasis