NDLI: Multi-alignment of orthologous genome regions in five species provides new insights into the evolutionary make-up of mammalian genomes

Content Provider	Springer Nature Link
Author	Jiang, Zhihua Michal, Jennifer J. Melville, Jenna S. Baltzer, Heather L.
Copyright Year	2005
Abstract	Evidence has shown that bacterial genomes have undergone random shuffling of genomic elements consisting of one to two genes. In order to delineate such genome-shuffling events in mammals, we constructed a high-resolution map of Sus scrofa chromosome 3 (SSC3) with a total of 116 genes/markers. Alignment of this pig map to orthologous regions in human, dog, mouse and rat led to the identification of 31 provisional conserved ancestral blocks (CABs) in these five species. Among them, only 3 CABs (<10%) had one gene, indicating that one-gene shuffling is not frequent in mammals. The sizes of CABs vary significantly within a species, but each may be relatively consistent in different species with a scale to species-genome evolution. The type and frequency of rearrangement events that takes place, either intra- or interchromosomal, depends on the evolutionary regions and species under comparison. Characterization of 36 tentative breakpoint regions flanking these 31 CABs indicated that they occupied ∼43 Mb in length and featured genome deserts, gene duplications, and birth/death of species-specific genes in humans. Identification of CABs provides an alternative for further determination of the evolutionary make-up of mammalian genomes.
Starting Page	707
Ending Page	715
Page Count	9
File Format	PDF
ISSN	09673849
Journal	Chromosome Research
Volume Number	13
Issue Number	7
e-ISSN	15736849
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2005-10-24
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	breakpoints chromosome evolution conserved ancestral blocks genomics mammal Human Genetics Cell Biology Plant Genetics & Genomics Animal Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Evolution of mammalian genome organization inferred from comparative gene mapping

Comparative genomics reveals birth and death of fragile regions in mammalian evolution

Chromosome-level genome assembly for giant panda provides novel insights into Carnivora chromosome evolution

Chromosome evolution at the origin of the ancestral vertebrate genome

Analysis of fine-scale mammalian evolutionary breakpoints provides new insight into their relation to genome organisation

Reconstruction of avian ancestral karyotypes reveals differences in the evolutionary history of macro- and microchromosomes

Insights into cereal genomes from two draft genome sequences of rice

Unfashionable crop species flourish in the 21st century

The bovine lactation genome: insights into the evolution of mammalian milk

Multi-alignment of orthologous genome regions in five species provides new insights into the evolutionary make-up of mammalian genomes

Similar Documents

Evolution of mammalian genome organization inferred from comparative gene mapping

Comparative genomics reveals birth and death of fragile regions in mammalian evolution

Chromosome-level genome assembly for giant panda provides novel insights into Carnivora chromosome evolution

Chromosome evolution at the origin of the ancestral vertebrate genome

Analysis of fine-scale mammalian evolutionary breakpoints provides new insight into their relation to genome organisation

Reconstruction of avian ancestral karyotypes reveals differences in the evolutionary history of macro- and microchromosomes

Insights into cereal genomes from two draft genome sequences of rice

Unfashionable crop species flourish in the 21st century

The bovine lactation genome: insights into the evolution of mammalian milk

Multi-alignment of orthologous genome regions in five species provides new insights into the evolutionary make-up of mammalian genomes