NDLI: Identification of mediator complex 26 (Crsp7) gametologs on platypus X1 and Y5 sex chromosomes: a candidate testis-determining gene in monotremes?

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Identification of mediator complex 26 (Crsp7) gametologs on platypus X1 and Y5 sex chromosomes: a candidate testis-determining gene in monotremes?

Content Provider	Springer Nature Link
Author	Tsend Ayush, Enkhjargal Kortschak, R. Daniel Bernard, Pascal Lim, Shu Ly Ryan, Janelle Rosenkranz, Ruben Borodina, Tatiana Dohm, Juliane C. Himmelbauer, Heinz Harley, Vincent R. Grützner, Frank
Copyright Year	2011
Abstract	The basal lineage of monotremes features an extraordinarily complex sex chromosome system which has provided novel insights into the evolution of mammalian sex chromosomes. Recently, sequence information from autosomes, X chromosomes, and XY-shared pseudoautosomal regions has become available. However, no gene has so far been described on any of the Y chromosome-specific regions. We analyzed sequences derived from Y-specific BAC clones to identify genes with potentially male-specific function. Here, we report the identification and characterization of the mediator complex protein gametologs on platypus Y5 (Crspy). We also identified the X-chromosomal copy which unexpectedly maps to X1 (Crspx). Sequence comparison shows extensive divergence between the X and Y copy, but we found no significant positive selection on either gametolog. Expression analysis shows widespread expression of Crspx. Crspy is expressed exclusively in males with particularly strong expression in testis and kidney. Reporter gene assays to investigate whether Crspx/y can act on the recently discovered mouse Sox9 testis-specific enhancer element did reveal a modest effect together with mouse Sox9 + Sf1, but showed overall no significant upregulation of the reporter gene. This is the first report of a differentiated functional male-specific gene on platypus Y chromosomes, providing new insights into sex chromosome evolution and a candidate gene for male-specific function in monotremes.
Starting Page	127
Ending Page	138
Page Count	12
File Format	PDF
ISSN	09673849
Journal	Chromosome Research
Volume Number	20
Issue Number	1
e-ISSN	15736849
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-01-04
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	evolution sex chromosomes Y chromosomes mediator complex sex determination mammals Tachyglossus aculeatus Ornithorhynchus anatinus Plant Genetics & Genomics Human Genetics Cell Biology Animal Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics

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Identification of mediator complex 26 (Crsp7) gametologs on platypus X1 and Y5 sex chromosomes: a candidate testis-determining gene in monotremes?

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Development of the dorsal and ventral thalamus in platypus (Ornithorhynchus anatinus) and short-beaked echidna (Tachyglossus aculeatus)

Identification of mediator complex 26 (Crsp7) gametologs on platypus X1 and Y5 sex chromosomes: a candidate testis-determining gene in monotremes?

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Identification of mediator complex 26 (Crsp7) gametologs on platypus X1 and Y5 sex chromosomes: a candidate testis-determining gene in monotremes?

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Identification of mediator complex 26 (Crsp7) gametologs on platypus X1 and Y5 sex chromosomes: a candidate testis-determining gene in monotremes?