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| Content Provider | Springer Nature Link |
|---|---|
| Author | Moraes, Tarsila Barros Jacques, Carlos Eduardo Diaz Rosa, Andrea Pereira Dalazen, Giovana Reche Terra, Melaine Coelho, Juliana Gonzalez Dutra Filho, Carlos Severo |
| Copyright Year | 2012 |
| Abstract | Phenylketonuria (PKU) is an inherited metabolic disorder caused by deficiency of phenylalanine hydroxylase which leads to accumulation of phenylalanine and its metabolites in tissues of patients with severe neurological involvement. Recently, many studies in animal models or patients have reported the role of oxidative stress in PKU. In the present work we studied the effect of lipoic acid against oxidative stress in rat brain provoked by an animal model of hyperphenylalaninemia (HPA), induced by repetitive injections of phenylalanine and α-methylphenylalanine (a phenylalanine hydroxylase inhibitor) for 7 days, on some oxidative stress parameters. Lipoic acid prevented alterations on catalase (CAT) and superoxide dismutase (SOD), and the oxidative damage of lipids, proteins, and DNA observed in HPA rats. In addition, lipoic acid diminished reactive species generation compared to HPA group which was positively correlated to SOD/CAT ratio. We also observed that in vitro Phe inhibited CAT activity while phenyllactic and phenylacetic acids stimulated superoxide dismutase activity. These results demonstrate the efficacy of lipoic acid to prevent oxidative stress induced by HPA model in rats. The possible benefits of lipoic acid administration to PKU patients should be considered. |
| Starting Page | 253 |
| Ending Page | 260 |
| Page Count | 8 |
| File Format | |
| ISSN | 02724340 |
| Journal | Cellular and Molecular Neurobiology |
| Volume Number | 33 |
| Issue Number | 2 |
| e-ISSN | 15736830 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2012-12-12 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | Hyperphenylalaninemia Oxidative stress Catalase Superoxide dismutase Lipoic acid Rat brain Neurosciences Cell Biology Neurobiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Cellular and Molecular Neuroscience |
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