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| Content Provider | Springer Nature Link |
|---|---|
| Author | Liu, Chao Liu, Chun Liu, Hanzhang Gong, Leilei Tao, Tao Shen, Yifen Zhu, Shunxing Shen, Aiguo |
| Copyright Year | 2016 |
| Abstract | Ubiquitinating enzymes catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzyme (DUB) action. Ubiquitin-specific protease 4 (USP4) is a member of the ubiquitin-specific protease (USP) family of DUBs that has a role in spliceosome regulation. In the present study, we demonstrated that USP4 may be involved in neuronal apoptosis in the processes of intracerebral hemorrhage (ICH). We obtained a significant up-regulation of USP4 in neurons adjacent to the hematoma following ICH by the results of Western blot, immunohistochemistry, and immunofluorescence. Increasing USP4 level was found to be accompanied by the up-regulation of active caspase-3, γH2AX, Bax, and decreased expression of Bcl-2. In addition, USP4 co-localized well with γH2AX in the nucleus in the ICH model and hemin-induced apoptosis model. Moreover, in vitro study, knocking down USP4 by USP4-specific siRNA in PC12 cells reduced active caspase-3 expression. All these results above suggested that USP4 may be involved in neuronal apoptosis after ICH. |
| Starting Page | 427 |
| Ending Page | 435 |
| Page Count | 9 |
| File Format | |
| ISSN | 02724340 |
| Journal | Cellular and Molecular Neurobiology |
| Volume Number | 37 |
| Issue Number | 3 |
| e-ISSN | 15736830 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2016-04-25 |
| Publisher Place | New York |
| Access Restriction | Subscribed |
| Subject Keyword | Intracerebral hemorrhage USP4 Neuronal apoptosis Adult rats Neurosciences Cell Biology Neurobiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Cellular and Molecular Neuroscience |
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