NDLI: Bioactivation of knitted cellulose scaffolds by strontium

Content Provider	Springer Nature Link
Author	Brandt, Heike Müller, Frank A. Greil, Peter
Copyright Year	2007
Abstract	Strontium has attained increasing interest in the treatment of osteoporosis due to its anabolic as well as antiresorptive activity. Knitted cellulose scaffolds with a porosity suitable to promote bone tissue ingrowth and vascularisation were doped with SrCO3. The in vitro bioactivity of the modified scaffolds was proven by formation of hydroxyapatite during exposure to simulated body fluid. The Sr-release kinetics during static exposure to simulated body fluid is dominated by an accelerated Sr-release in the initial state followed by a reduced release corresponding to a diffusion controlled rate. Microstructural analyses indicate that initially precipitated SrCO3 transforms to Sr x Ca1−x CO3 solid solutions that subsequently serve as a template for the precipitation of bone like carbonated hydroxyapatite under conditions simulating the inorganic part of the human blood plasma.
Starting Page	275
Ending Page	283
Page Count	9
File Format	PDF
ISSN	09690239
Journal	Cellulose
Volume Number	15
Issue Number	2
e-ISSN	1572882X
Language	English
Publisher	Springer Netherlands
Publisher Date	2007-09-11
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cellulose Strontium Drug release Biomimetic apatite Polysaccharide Bioactivity Polymer Sciences Organic Chemistry Physical Chemistry Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Polymers and Plastics

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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