NDLI: C-reactive protein, sodium azide, and endothelial connexin43 gap junctions

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C-reactive protein, sodium azide, and endothelial connexin43 gap junctions

Content Provider	Springer Nature Link
Author	Wang, Hsueh Hsiao Yeh, Hung I Wang, Chi Young Su, Cheng Huang Wu, Yih Jer Tseng, Yuen Yi Lin, Yi Chun Tsai, Cheng Ho
Copyright Year	2009
Abstract	We investigated the effect of C-reactive protein (CRP) and sodium azide (NaN3) on endothelial Cx43 gap junctions. Human aortic endothelial cells (HAEC) were treated with (a) detoxified CRP, (b) detoxified dialyzed CRP, (c) detoxified dialyzed CRP plus NaN3, (d) NaN3, or (e) dialyzed NaN3. The concentration of CRP in all preparations was fixed to 25 μg/ml and that of NaN3 in the preparations of (c) to (e) was equivalent to that contained in the 25 μg/ml CRP purchased commercially. The results showed that both the expression of Cx43 protein and gap junctional communication function post-48-h incubation were reduced and inhibited by the detoxified CRP, NaN3, or detoxified dialyzed CRP plus NaN3, but not by the detoxified dialyzed CRP or dialyzed NaN3. Reverse transcription-polymerase chain reaction analysis of cells treated for 72 h also showed a pattern of transcriptional regulation essentially the same as that for the proteins. We concluded that CRP does not have a significant effect on Cx43 gap junctions of HAEC, but NaN3 inhibited the viability of cells and downregulate their junctions.
Starting Page	153
Ending Page	163
Page Count	11
File Format	PDF
ISSN	07422091
Journal	Cell Biology and Toxicology
Volume Number	26
Issue Number	2
e-ISSN	15736822
Language	English
Publisher	Springer Netherlands
Publisher Date	2009-05-05
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Connexin43 C-reactive protein Endothelial cells Gap junction Sodium azide Biochemistry Pharmacology/Toxicology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Health, Toxicology and Mutagenesis Toxicology

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