NDLI: L-carnitine modulates blood platelet oxidative stress

Content Provider	Springer Nature Link
Author	Saluk Juszczak, Joanna Olas, Beata Wachowicz, Barbara Glowacki, Rafal Bald, Edward
Copyright Year	2010
Abstract	The oxidative stress induced by acute exertion may interfere with blood platelet activation. The beneficial effect of l-carnitine (γ-trimethylamino-β-hydroxybutyric acid) on oxidative stress in blood platelets has not been fully investigated; however, different studies indicate that this compound modulates platelet functions. The aim of our study was to assess the effects of l-carnitine on platelet activation and oxidative/nitrative protein damage (determined by the levels of protein carbonyl groups, thiol groups, and 3-nitrotyrosine residues) in resting blood platelets or platelets treated with peroxynitrite (ONOO−, a strong physiological oxidant) in vitro. We also investigated the effects of l-carnitine on the level of platelet glutathione and on the formation of superoxide anion radicals $$ \left( {{\hbox{O}}_2^{ - \bullet }} \right) $$ , lipid peroxidation measured by thiobarbituric acid reactive substances (TBARS) in blood platelets stimulated by thrombin (a strong physiological agonist), and platelet aggregation induced by adenosine diphosphate (a strong physiological stimulator). We have observed that carnitine decreases platelet activation (measured by platelet aggregation, the generation of $$ {\hbox{O}}_2^{ - \bullet } $$ , and TBARS production). Moreover, our results in vitro demonstrate that carnitine may protect against oxidation of thiol groups induced by ONOO−. Thus, carnitine may have some protectory effects against oxidative changes induced in blood platelets.
Starting Page	355
Ending Page	365
Page Count	11
File Format	PDF
ISSN	07422091
Journal	Cell Biology and Toxicology
Volume Number	26
Issue Number	4
e-ISSN	15736822
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-01-13
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Blood platelets Carnitine Oxidative stress Peroxynitrite Biochemistry Pharmacology/Toxicology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Health, Toxicology and Mutagenesis Toxicology

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