NDLI: Dibutyltin activates MAP kinases in human natural killer cells, in vitro

Content Provider	Springer Nature Link
Author	Odman Ghazi, Sabah O. Abraha, Abraham Isom, Erica Taylor Whalen, Margaret M.
Copyright Year	2010
Abstract	Previous studies have shown that dibutyltin (DBT) interferes with the function of human natural killer (NK) cells, diminishing their capacity to destroy tumor cells, in vitro. DBT is a widespread environmental contaminant and has been found in human blood. As NK cells are our primary immune defense against tumor cells, it is important to understand the mechanism by which DBT interferes with their function. The current study examines the effects of DBT exposures on key enzymes in the signaling pathway that regulates NK responsiveness to tumor cells. These include several protein tyrosine kinases (PTKs), mitogen-activated protein kinases (MAPKs), and mitogen-activated protein kinase kinases (MAP2Ks). The results showed that in vitro exposures of NK cells to DBT had no effect on PTKs. However, exposures to DBT for as little as 10 min were able to increase the phosphorylation (activation) of the MAPKs. The DBT-induced activations of these MAPKs appear to be due to DBT-induced activations of the immediate upstream activators of the MAPKs, MAP2Ks. The results suggest that DBT-interference with the MAPK signaling pathway is a consequence of DBT exposures, which could account for DBT-induced decreases in NK function.
Starting Page	469
Ending Page	479
Page Count	11
File Format	PDF
ISSN	07422091
Journal	Cell Biology and Toxicology
Volume Number	26
Issue Number	5
e-ISSN	15736822
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-03-24
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	MAP kinases MAP kinase kinases Protein tyrosine kinases NK cells Dibutyltin Biochemistry Pharmacology/Toxicology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Health, Toxicology and Mutagenesis Toxicology

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