NDLI: Hypoxia, inflammation, and the tumor microenvironment in metastatic disease

Content Provider	Springer Nature Link
Author	Finger, Elizabeth C. Giaccia, Amato J.
Copyright Year	2010
Abstract	Metastasis, the leading cause of cancer deaths, is an intricate process involving many important tumor and stromal proteins that have yet to be fully defined. This review discusses critical components necessary for the metastatic cascade, including hypoxia, inflammation, and the tumor microenvironment. More specifically, this review focuses on tumor cell and stroma interactions, which allow cell detachment from a primary tumor, intravasation to the blood stream, and extravasation at a distant site where cells can seed and tumor metastases can form. Central players involved in this process and discussed in this review include integrins, matrix metalloproteinases, and soluble growth factors/matrix proteins, including the connective tissue growth factor and lysyl oxidase.
Starting Page	285
Ending Page	293
Page Count	9
File Format	PDF
ISSN	01677659
Journal	Cancer and Metastasis Reviews
Volume Number	29
Issue Number	2
e-ISSN	15737233
Language	English
Publisher	Springer US
Publisher Date	2010-04-15
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Connective tissue growth factor Lysyl oxidase Metastasis Hypoxia Biomedicine general Oncology Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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Hypoxia, inflammation, and the tumor microenvironment in metastatic disease