NDLI: Hereditary ovarian cancers: from BRCA mutations to clinical management. A modern appraisal

Content Provider	Springer Nature Link
Author	Tinelli, Andrea Malvasi, Antonio Leo, Giuseppe Vergara, Daniele Pisanò, Maurizio Ciccarese, Mariangela Chiuri, Vincenzo Emanuele Lorusso, Vito
Copyright Year	2010
Abstract	In the past few years, ovarian cancer research has focused increasingly on disease prevention; but an increasing number of women refer to gynecology and clinical genetics clinics with a family history of ovarian cancer and inherited familial mutations. The interest on the issue has increased also due to the identification of BReast CAncer1 (BRCA1) and BRCA2 genes mutations. The importance of recognizing the characteristics of hereditary ovarian cancer (HOC) and manage women at risk appropriately will provide more accurate care of the high-risk population. Women at risk can be identified by pedigree analysis and may receive counseling from interdisciplinary cancer genetics clinics, while those at high risk need to receive genetic testing. Risk calculation programs define risks and assist in decision-making in clinical options and genetic testing; they provide information on the risks of the disease, mutation status, and the use of genetic testing in the management of high-risk families. Furthermore, while a large number of surrogate preliminary markers have been identified, there are still limited studies on ovarian cancer genomics. Different options for risk management of HOC are available: surveillance, chemoprevention and prophylactic surgery. Surveillance in HOC high-risk patients is still not accurate. Chemoprevention is currently a controversial topic, because a number of major issues still need to be addressed in developing and testing agents for ovarian cancer chemoprevention. Prophylactic surgery has been shown to effectively decrease cancer risk, and it has the possibility to substantially reduce ovarian cancer mortality.
Starting Page	339
Ending Page	350
Page Count	12
File Format	PDF
ISSN	01677659
Journal	Cancer and Metastasis Reviews
Volume Number	29
Issue Number	2
e-ISSN	15737233
Language	English
Publisher	Springer US
Publisher Date	2010-04-21
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hereditary ovarian cancer BRCA Prophylactic surgery Genetics Genetic testing HNPCC Laparoscopy Oophorectomy Counseling Risk assessment Biomedicine general Oncology Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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Hereditary ovarian cancers: from BRCA mutations to clinical management. A modern appraisal.

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