NDLI: Given breast cancer, does breast size matter? Data from a prospective breast cancer cohort

Content Provider	Springer Nature Link
Author	Markkula, Andrea Bromée, Anna Henningson, Maria Hietala, Maria Ringberg, Anita Ingvar, Christian Rose, Carsten Jernström, Helena
Copyright Year	2012
Abstract	Body mass index (BMI), waist-to-hip ratio (WHR), and tumor characteristics affect disease-free survival. Larger breast size may increase breast cancer risk, but its influence on disease-free survival is unclear. The purpose of this study was to elucidate whether breast size independently influenced disease-free survival in breast cancer patients.Body measurements were obtained preoperatively from 772 breast cancer patients in a population-based ongoing cohort from southern Sweden. The research nurse measured breast volumes with plastic cups used by plastic surgeons doing breast reductions. Clinical data were obtained from patient charts and pathology reports.Patients with a BMI ≥ 25 kg/m2 had larger tumors (p < 0.001) and more axillary nodal involvement (p = 0.030). Patients with a WHR > 0.85 had larger tumors (p = 0.013), more advanced histological grade (p = 0.0016), and more axillary nodal involvement (p = 0.012). Patients with right + left breast volume ≥ 850 mL were more likely to have larger tumor sizes (p = 0.018), more advanced histological grade (p = 0.031), and more axillary nodal involvement (p = 0.025). There were 62 breast cancer events during the 7-year follow-up. Breast volume ≥ 850 mL was associated with shorter disease-free survival (p = 0.004) and distant metastasis-free survival (p = 0.001) in patients with estrogen receptor (ER)-positive tumors independent of other anthropometric measurements and age. In patients with ER-positive tumors, breast size was an independent predictor of shorter disease-free (HR 3.64; 95 % CI 1.42–9.35) and distant metastasis-free survival (HR 6.33; 95 %CI 1.36–29.43), adjusted for tumor characteristics, BMI, age, and treatment.A simple and cheap anthropometric measurement with standardized tools may help identify a subgroup of patients in need of tailored breast cancer therapy.
Starting Page	1307
Ending Page	1316
Page Count	10
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	23
Issue Number	8
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-06-14
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Breast cancer Prognosis Body mass index Waist-to-hip ratio Breast size Hematology Oncology Epidemiology Public Health/Gesundheitswesen Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Body fat distribution and breast cancer risk: findings from the Nigerian breast cancer study

A prospective study of waist circumference and body mass index in relation to colorectal cancer incidence

Post-diagnosis adiposity and survival among breast cancer patients: influence of breast cancer subtype

Waist circumference, body mass index, and postmenopausal breast cancer incidence in the Cancer Prevention Study-II Nutrition Cohort

Influence of body mass index on prognosis in gynecological malignancies

Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts

Young adulthood body mass index and risk of cancer in later adulthood: historical cohort study

Physical activity, body size and composition, and risk of ovarian cancer

Impact of body mass index in Korean patients with renal cell carcinoma

Given breast cancer, does breast size matter? Data from a prospective breast cancer cohort

Similar Documents

Body fat distribution and breast cancer risk: findings from the Nigerian breast cancer study

A prospective study of waist circumference and body mass index in relation to colorectal cancer incidence

Post-diagnosis adiposity and survival among breast cancer patients: influence of breast cancer subtype

Waist circumference, body mass index, and postmenopausal breast cancer incidence in the Cancer Prevention Study-II Nutrition Cohort

Influence of body mass index on prognosis in gynecological malignancies

Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts

Young adulthood body mass index and risk of cancer in later adulthood: historical cohort study

Physical activity, body size and composition, and risk of ovarian cancer

Impact of body mass index in Korean patients with renal cell carcinoma

Given breast cancer, does breast size matter? Data from a prospective breast cancer cohort